Lymphocyte crosstalk is required for monocyte-intrinsic trained immunity to Plasmodium falciparum

Plasmodium falciparum (P. falciparum) induces trained innate immune responses in vitro, where initial stimulation of adherent PBMCs with P. falciparum–infected RBCs (iRBCs) results in hyperresponsiveness to subsequent ligation of TLR2. This response correlates with the presence of T and B lymphocyte...

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Detalles Bibliográficos
Autores principales: Crabtree, Juliet N., Caffrey, Daniel R., de Souza Silva, Leandro, Kurt-Jones, Evelyn A., Dobbs, Katherine, Dent, Arlene, Fitzgerald, Katherine A., Golenbock, Douglas T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9151696/
https://www.ncbi.nlm.nih.gov/pubmed/35642634
http://dx.doi.org/10.1172/JCI139298

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