The ZIP8/SIRT1 axis regulates alveolar progenitor cell renewal in aging and idiopathic pulmonary fibrosis

Type 2 alveolar epithelial cells (AEC2s) function as progenitor cells in the lung. We have shown previously that failure of AEC2 regeneration results in progressive lung fibrosis in mice and is a cardinal feature of idiopathic pulmonary fibrosis (IPF). In this study, we identified deficiency of a sp...

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Detalles Bibliográficos
Autores principales: Liang, Jiurong, Huang, Guanling, Liu, Xue, Taghavifar, Forough, Liu, Ningshan, Wang, Yizhou, Deng, Nan, Yao, Changfu, Xie, Ting, Kulur, Vrishika, Dai, Kristy, Burman, Ankita, Rowan, Simon C., Weigt, S. Samuel, Belperio, John, Stripp, Barry, Parks, William C., Jiang, Dianhua, Noble, Paul W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9151700/
https://www.ncbi.nlm.nih.gov/pubmed/35389887
http://dx.doi.org/10.1172/JCI157338

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