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α Cell dysfunction in islets from nondiabetic, glutamic acid decarboxylase autoantibody–positive individuals

BACKGROUND: Multiple islet autoantibodies (AAbs) predict the development of type 1 diabetes (T1D) and hyperglycemia within 10 years. By contrast, T1D develops in only approximately 15% of individuals who are positive for single AAbs (generally against glutamic acid decarboxylase [GADA]); hence, the...

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Detalles Bibliográficos
Autores principales:	Doliba, Nicolai M., Rozo, Andrea V., Roman, Jeffrey, Qin, Wei, Traum, Daniel, Gao, Long, Liu, Jinping, Manduchi, Elisabetta, Liu, Chengyang, Golson, Maria L., Vahedi, Golnaz, Naji, Ali, Matschinsky, Franz M., Atkinson, Mark A., Powers, Alvin C., Brissova, Marcela, Kaestner, Klaus H., Stoffers, Doris A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2022
Materias:	Clinical Medicine
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9151702/ https://www.ncbi.nlm.nih.gov/pubmed/35642629 http://dx.doi.org/10.1172/JCI156243

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