Epigenetic regulator UHRF1 orchestrates proinflammatory gene expression in rheumatoid arthritis in a suppressive manner

Rheumatoid arthritis (RA) is characterized by chronic synovial inflammation with aberrant epigenetic alterations, eventually leading to joint destruction. However, the epigenetic regulatory mechanisms underlying RA pathogenesis remain largely unknown. Here, we showed that ubiquitin-like containing P...

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Detalles Bibliográficos
Autores principales: Saeki, Noritaka, Inoue, Kazuki, Ideta-Otsuka, Maky, Watamori, Kunihiko, Mizuki, Shinichi, Takenaka, Katsuto, Igarashi, Katsuhide, Miura, Hiromasa, Takeda, Shu, Imai, Yuuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9151705/
https://www.ncbi.nlm.nih.gov/pubmed/35472067
http://dx.doi.org/10.1172/JCI150533

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