Inhibiting SCAP/SREBP exacerbates liver injury and carcinogenesis in murine nonalcoholic steatohepatitis

Enhanced de novo lipogenesis mediated by sterol regulatory element–binding proteins (SREBPs) is thought to be involved in nonalcoholic steatohepatitis (NASH) pathogenesis. In this study, we assessed the impact of SREBP inhibition on NASH and liver cancer development in murine models. Unexpectedly, S...

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Detalles Bibliográficos
Autores principales: Kawamura, Satoshi, Matsushita, Yuki, Kurosaki, Shigeyuki, Tange, Mizuki, Fujiwara, Naoto, Hayata, Yuki, Hayakawa, Yoku, Suzuki, Nobumi, Hata, Masahiro, Tsuboi, Mayo, Kishikawa, Takahiro, Kinoshita, Hiroto, Nakatsuka, Takuma, Sato, Masaya, Kudo, Yotaro, Hoshida, Yujin, Umemura, Atsushi, Eguchi, Akiko, Ikenoue, Tsuneo, Hirata, Yoshihiro, Uesugi, Motonari, Tateishi, Ryosuke, Tateishi, Keisuke, Fujishiro, Mitsuhiro, Koike, Kazuhiko, Nakagawa, Hayato
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9151706/
https://www.ncbi.nlm.nih.gov/pubmed/35380992
http://dx.doi.org/10.1172/JCI151895

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9151706/
https://www.ncbi.nlm.nih.gov/pubmed/35380992
http://dx.doi.org/10.1172/JCI151895

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