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The melanopsin-mediated pupil response is reduced in idiopathic hypersomnia with long sleep time

Idiopathic hypersomnia (IH), characterized by an excessive day-time sleepiness, a prolonged total sleep time on 24 h and/or a reduced sleep latency, affects 1 in 2000 individuals from the general population. However, IH remains underdiagnosed and inaccurately treated despite colossal social, profess...

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Autores principales: Rach, Héloïse, Kilic-Huck, Ulker, Reynaud, Eve, Hugueny, Laurence, Peiffer, Emilie, Roy de Belleplaine, Virginie, Fuchs, Fanny, Bourgin, Patrice, Geoffroy, Pierre A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9151765/
https://www.ncbi.nlm.nih.gov/pubmed/35637236
http://dx.doi.org/10.1038/s41598-022-13041-3
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author Rach, Héloïse
Kilic-Huck, Ulker
Reynaud, Eve
Hugueny, Laurence
Peiffer, Emilie
Roy de Belleplaine, Virginie
Fuchs, Fanny
Bourgin, Patrice
Geoffroy, Pierre A.
author_facet Rach, Héloïse
Kilic-Huck, Ulker
Reynaud, Eve
Hugueny, Laurence
Peiffer, Emilie
Roy de Belleplaine, Virginie
Fuchs, Fanny
Bourgin, Patrice
Geoffroy, Pierre A.
author_sort Rach, Héloïse
collection PubMed
description Idiopathic hypersomnia (IH), characterized by an excessive day-time sleepiness, a prolonged total sleep time on 24 h and/or a reduced sleep latency, affects 1 in 2000 individuals from the general population. However, IH remains underdiagnosed and inaccurately treated despite colossal social, professional and personal impacts. The pathogenesis of IH is poorly known, but recent works have suggested possible alterations of phototransduction. In this context, to identify biomarkers of IH, we studied the Post-Illumination Pupil Response (PIPR) using a specific pupillometry protocol reflecting the melanopsin-mediated pupil response in IH patients with prolonged total sleep time (TST > 660 min) and in healthy subjects. Twenty-eight patients with IH (women 86%, 25.4 year-old ± 4.9) and 29 controls (women 52%, 27.1 year-old ± 3.9) were included. After correction on baseline pupil diameter, the PIPR was compared between groups and correlated to sociodemographic and sleep parameters. We found that patients with IH had a lower relative PIPR compared to controls (32.6 ± 9.9% vs 38.5 ± 10.2%, p = 0.037) suggesting a reduced melanopsin response. In addition, the PIPR was not correlated to age, chronotype, TST, nor depressive symptoms. The melanopsin-specific PIPR may be an innovative trait marker of IH and the pupillometry might be a promising tool to better characterize hypersomnia.
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spelling pubmed-91517652022-06-01 The melanopsin-mediated pupil response is reduced in idiopathic hypersomnia with long sleep time Rach, Héloïse Kilic-Huck, Ulker Reynaud, Eve Hugueny, Laurence Peiffer, Emilie Roy de Belleplaine, Virginie Fuchs, Fanny Bourgin, Patrice Geoffroy, Pierre A. Sci Rep Article Idiopathic hypersomnia (IH), characterized by an excessive day-time sleepiness, a prolonged total sleep time on 24 h and/or a reduced sleep latency, affects 1 in 2000 individuals from the general population. However, IH remains underdiagnosed and inaccurately treated despite colossal social, professional and personal impacts. The pathogenesis of IH is poorly known, but recent works have suggested possible alterations of phototransduction. In this context, to identify biomarkers of IH, we studied the Post-Illumination Pupil Response (PIPR) using a specific pupillometry protocol reflecting the melanopsin-mediated pupil response in IH patients with prolonged total sleep time (TST > 660 min) and in healthy subjects. Twenty-eight patients with IH (women 86%, 25.4 year-old ± 4.9) and 29 controls (women 52%, 27.1 year-old ± 3.9) were included. After correction on baseline pupil diameter, the PIPR was compared between groups and correlated to sociodemographic and sleep parameters. We found that patients with IH had a lower relative PIPR compared to controls (32.6 ± 9.9% vs 38.5 ± 10.2%, p = 0.037) suggesting a reduced melanopsin response. In addition, the PIPR was not correlated to age, chronotype, TST, nor depressive symptoms. The melanopsin-specific PIPR may be an innovative trait marker of IH and the pupillometry might be a promising tool to better characterize hypersomnia. Nature Publishing Group UK 2022-05-30 /pmc/articles/PMC9151765/ /pubmed/35637236 http://dx.doi.org/10.1038/s41598-022-13041-3 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Rach, Héloïse
Kilic-Huck, Ulker
Reynaud, Eve
Hugueny, Laurence
Peiffer, Emilie
Roy de Belleplaine, Virginie
Fuchs, Fanny
Bourgin, Patrice
Geoffroy, Pierre A.
The melanopsin-mediated pupil response is reduced in idiopathic hypersomnia with long sleep time
title The melanopsin-mediated pupil response is reduced in idiopathic hypersomnia with long sleep time
title_full The melanopsin-mediated pupil response is reduced in idiopathic hypersomnia with long sleep time
title_fullStr The melanopsin-mediated pupil response is reduced in idiopathic hypersomnia with long sleep time
title_full_unstemmed The melanopsin-mediated pupil response is reduced in idiopathic hypersomnia with long sleep time
title_short The melanopsin-mediated pupil response is reduced in idiopathic hypersomnia with long sleep time
title_sort melanopsin-mediated pupil response is reduced in idiopathic hypersomnia with long sleep time
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9151765/
https://www.ncbi.nlm.nih.gov/pubmed/35637236
http://dx.doi.org/10.1038/s41598-022-13041-3
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