SARS-CoV-2 RNA in exhaled air of hospitalized COVID-19 patients

Knowledge about contagiousness is key to accurate management of hospitalized COVID-19 patients. Epidemiological studies suggest that in addition to transmission through droplets, aerogenic SARS-CoV-2 transmission contributes to the spread of infection. However, the presence of virus in exhaled air h...

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Detalles Bibliográficos
Autores principales: Kurver, Lisa, van den Kieboom, Corné H., Lanke, Kjerstin, Diavatopoulos, Dimitri A., Overheul, Gijs J., Netea, Mihai G., ten Oever, Jaap, van Crevel, Reinout, Mulders-Manders, Karin, van de Veerdonk, Frank L., Wertheim, Heiman, Schouten, Jeroen, Rahamat-Langendoen, Janette, van Rij, Ronald P., Bousema, Teun, van Laarhoven, Arjan, de Jonge, Marien I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9151771/
https://www.ncbi.nlm.nih.gov/pubmed/35637284
http://dx.doi.org/10.1038/s41598-022-13008-4
Descripción
Sumario:Knowledge about contagiousness is key to accurate management of hospitalized COVID-19 patients. Epidemiological studies suggest that in addition to transmission through droplets, aerogenic SARS-CoV-2 transmission contributes to the spread of infection. However, the presence of virus in exhaled air has not yet been sufficiently demonstrated. In pandemic situations low tech disposable and user-friendly bedside devices are required, while commercially available samplers are unsuitable for application in patients with respiratory distress. We included 49 hospitalized COVID-19 patients and used a disposable modular breath sampler to measure SARS-CoV-2 RNA load in exhaled air samples and compared these to SARS-CoV-2 RNA load of combined nasopharyngeal throat swabs and saliva. Exhaled air sampling using the modular breath sampler has proven feasible in a clinical COVID-19 setting and demonstrated viral detection in 25% of the patients.

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