Cargando…

Simultaneous Occurrence of Immune-Mediated Thrombocytopenia and Myocarditis After mRNA-1273 COVID-19 Vaccination: A Case Report

With the global spread of severe acute respiratory syndrome coronavirus 2, several vaccines were developed; messenger RNA (mRNA) vaccines have recently been widely used worldwide. However, the incidence of myocarditis following mRNA vaccination is increasing; although the cause of myocarditis has no...

Descripción completa

Detalles Bibliográficos
Autores principales: Bae, Dae-Hwan, Kim, Min, Lee, Dae In, Lee, Ju-Hee, Kim, Sangmin, Lee, Sang Yeub, Bae, Jang-Whan, Hwang, Kyung-Kuk, Kim, Dong-Woon, Cho, Myeong-Chan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Academy of Medical Sciences 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9151992/
https://www.ncbi.nlm.nih.gov/pubmed/35638196
http://dx.doi.org/10.3346/jkms.2022.37.e169
_version_ 1784717555164774400
author Bae, Dae-Hwan
Kim, Min
Lee, Dae In
Lee, Ju-Hee
Kim, Sangmin
Lee, Sang Yeub
Bae, Jang-Whan
Hwang, Kyung-Kuk
Kim, Dong-Woon
Cho, Myeong-Chan
author_facet Bae, Dae-Hwan
Kim, Min
Lee, Dae In
Lee, Ju-Hee
Kim, Sangmin
Lee, Sang Yeub
Bae, Jang-Whan
Hwang, Kyung-Kuk
Kim, Dong-Woon
Cho, Myeong-Chan
author_sort Bae, Dae-Hwan
collection PubMed
description With the global spread of severe acute respiratory syndrome coronavirus 2, several vaccines were developed; messenger RNA (mRNA) vaccines have recently been widely used worldwide. However, the incidence of myocarditis following mRNA vaccination is increasing; although the cause of myocarditis has not yet been clearly identified, it is presumed to be caused by a problem in the innate immune system. Immune-mediated thrombocytopenia (ITP) after vaccination is rare but has been reported and is also assumed to occur by the same mechanism. We report the first case of simultaneous myocarditis and ITP after mRNA vaccination. A 38-year-old woman presented with chest pain, mild dyspnea, and sweating after vaccination with mRNA-1273 vaccine (Moderna) 4 days prior to admission. Upon admission to the emergency department, cardiac enzymes were elevated; blood test performed 5 months ago showed normal platelet count, but severe thrombocytopenia was observed upon admission. After administration of intravenous immunoglobulin, the platelet count improved; subsequently, myocarditis was observed on endomyocardial biopsy. Thus, myocarditis and ITP were judged to have occurred simultaneously due to the expression of the innate immune system markers after mRNA vaccination. The patient was discharged on day 6 of admission.
format Online
Article
Text
id pubmed-9151992
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher The Korean Academy of Medical Sciences
record_format MEDLINE/PubMed
spelling pubmed-91519922022-06-04 Simultaneous Occurrence of Immune-Mediated Thrombocytopenia and Myocarditis After mRNA-1273 COVID-19 Vaccination: A Case Report Bae, Dae-Hwan Kim, Min Lee, Dae In Lee, Ju-Hee Kim, Sangmin Lee, Sang Yeub Bae, Jang-Whan Hwang, Kyung-Kuk Kim, Dong-Woon Cho, Myeong-Chan J Korean Med Sci Case Report With the global spread of severe acute respiratory syndrome coronavirus 2, several vaccines were developed; messenger RNA (mRNA) vaccines have recently been widely used worldwide. However, the incidence of myocarditis following mRNA vaccination is increasing; although the cause of myocarditis has not yet been clearly identified, it is presumed to be caused by a problem in the innate immune system. Immune-mediated thrombocytopenia (ITP) after vaccination is rare but has been reported and is also assumed to occur by the same mechanism. We report the first case of simultaneous myocarditis and ITP after mRNA vaccination. A 38-year-old woman presented with chest pain, mild dyspnea, and sweating after vaccination with mRNA-1273 vaccine (Moderna) 4 days prior to admission. Upon admission to the emergency department, cardiac enzymes were elevated; blood test performed 5 months ago showed normal platelet count, but severe thrombocytopenia was observed upon admission. After administration of intravenous immunoglobulin, the platelet count improved; subsequently, myocarditis was observed on endomyocardial biopsy. Thus, myocarditis and ITP were judged to have occurred simultaneously due to the expression of the innate immune system markers after mRNA vaccination. The patient was discharged on day 6 of admission. The Korean Academy of Medical Sciences 2022-05-18 /pmc/articles/PMC9151992/ /pubmed/35638196 http://dx.doi.org/10.3346/jkms.2022.37.e169 Text en © 2022 The Korean Academy of Medical Sciences. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Bae, Dae-Hwan
Kim, Min
Lee, Dae In
Lee, Ju-Hee
Kim, Sangmin
Lee, Sang Yeub
Bae, Jang-Whan
Hwang, Kyung-Kuk
Kim, Dong-Woon
Cho, Myeong-Chan
Simultaneous Occurrence of Immune-Mediated Thrombocytopenia and Myocarditis After mRNA-1273 COVID-19 Vaccination: A Case Report
title Simultaneous Occurrence of Immune-Mediated Thrombocytopenia and Myocarditis After mRNA-1273 COVID-19 Vaccination: A Case Report
title_full Simultaneous Occurrence of Immune-Mediated Thrombocytopenia and Myocarditis After mRNA-1273 COVID-19 Vaccination: A Case Report
title_fullStr Simultaneous Occurrence of Immune-Mediated Thrombocytopenia and Myocarditis After mRNA-1273 COVID-19 Vaccination: A Case Report
title_full_unstemmed Simultaneous Occurrence of Immune-Mediated Thrombocytopenia and Myocarditis After mRNA-1273 COVID-19 Vaccination: A Case Report
title_short Simultaneous Occurrence of Immune-Mediated Thrombocytopenia and Myocarditis After mRNA-1273 COVID-19 Vaccination: A Case Report
title_sort simultaneous occurrence of immune-mediated thrombocytopenia and myocarditis after mrna-1273 covid-19 vaccination: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9151992/
https://www.ncbi.nlm.nih.gov/pubmed/35638196
http://dx.doi.org/10.3346/jkms.2022.37.e169
work_keys_str_mv AT baedaehwan simultaneousoccurrenceofimmunemediatedthrombocytopeniaandmyocarditisaftermrna1273covid19vaccinationacasereport
AT kimmin simultaneousoccurrenceofimmunemediatedthrombocytopeniaandmyocarditisaftermrna1273covid19vaccinationacasereport
AT leedaein simultaneousoccurrenceofimmunemediatedthrombocytopeniaandmyocarditisaftermrna1273covid19vaccinationacasereport
AT leejuhee simultaneousoccurrenceofimmunemediatedthrombocytopeniaandmyocarditisaftermrna1273covid19vaccinationacasereport
AT kimsangmin simultaneousoccurrenceofimmunemediatedthrombocytopeniaandmyocarditisaftermrna1273covid19vaccinationacasereport
AT leesangyeub simultaneousoccurrenceofimmunemediatedthrombocytopeniaandmyocarditisaftermrna1273covid19vaccinationacasereport
AT baejangwhan simultaneousoccurrenceofimmunemediatedthrombocytopeniaandmyocarditisaftermrna1273covid19vaccinationacasereport
AT hwangkyungkuk simultaneousoccurrenceofimmunemediatedthrombocytopeniaandmyocarditisaftermrna1273covid19vaccinationacasereport
AT kimdongwoon simultaneousoccurrenceofimmunemediatedthrombocytopeniaandmyocarditisaftermrna1273covid19vaccinationacasereport
AT chomyeongchan simultaneousoccurrenceofimmunemediatedthrombocytopeniaandmyocarditisaftermrna1273covid19vaccinationacasereport