Cargando…

Evaluation of Risk and Preventive Factors for Necrotizing Enterocolitis in Premature Newborns. A Systematic Review of the Literature

Necrotizing enterocolitis (NEC) is a serious condition related to prematurity and the initiation of enteral feeding. In this article, we review the evidence published in recent years on necrotizing enterocolitis risk factors (prematurity, feeding with low-weight formula, existence of intestinal dysb...

Descripción completa

Detalles Bibliográficos
Autores principales: Campos-Martinez, Ana M., Expósito-Herrera, J., Gonzalez-Bolívar, M., Fernández-Marin, E., Uberos, Jose
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9152085/
https://www.ncbi.nlm.nih.gov/pubmed/35656377
http://dx.doi.org/10.3389/fped.2022.874976
_version_ 1784717565908484096
author Campos-Martinez, Ana M.
Expósito-Herrera, J.
Gonzalez-Bolívar, M.
Fernández-Marin, E.
Uberos, Jose
author_facet Campos-Martinez, Ana M.
Expósito-Herrera, J.
Gonzalez-Bolívar, M.
Fernández-Marin, E.
Uberos, Jose
author_sort Campos-Martinez, Ana M.
collection PubMed
description Necrotizing enterocolitis (NEC) is a serious condition related to prematurity and the initiation of enteral feeding. In this article, we review the evidence published in recent years on necrotizing enterocolitis risk factors (prematurity, feeding with low-weight formula, existence of intestinal dysbiosis) and protective factors (human milk or donated milk supply, supplementation of human milk with oligosaccharides, probiotics administration, and the determination of disease predictive biomarkers). A systematic review was conducted of preventive, risk and predictive factors for necrotizing enterocolitis in neonates prior to 37 weeks' gestational age, based on a literature search for clinical trials, meta-analyses, randomized controlled trials and systematic reviews published between January 2018 and October 2021. For this purpose, the PubMed, MEDLINE, and Cochrane Library databases were consulted. The literature search obtained 113 articles, of which 19 were selected for further analysis after applying the inclusion and exclusion criteria. The conclusions drawn from this analysis were that adequate knowledge of risk factors that can be prevented or modified (such as alteration of the intestinal microbiota, oxidative stress, metabolic dysfunction at birth, or alteration of the immunity modulation) can reduce the incidence of NEC in premature infants. These factors include the supplementation of enteral nutrition with human milk oligosaccharides (with prebiotic and immunomodulatory effects), the combined administration of probiotics (especially the Lactobacillus spp and Bifidobacterium spp combination, which inhibits bacterial adhesion effects, improves the intestinal mucosa barrier function, strengthens the innate and adaptive immune system and increases the secretion of bioactive metabolites), the supplementation of human milk with lactoferrin and the use of donated milk fortified in accordance with the characteristics of the premature newborn. The determination of factors that can predict the existence of NEC, such as fecal calprotectin, increased TLR4 activity, and IL6 receptor, can lead to an early diagnosis of NEC. Although further studies should be conducted to determine the values of predictive biomarkers of NEC, and/or the recommended doses and strains of probiotics, lactoferrin or oligosaccharides, the knowledge acquired in recent years is encouraging.
format Online
Article
Text
id pubmed-9152085
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-91520852022-06-01 Evaluation of Risk and Preventive Factors for Necrotizing Enterocolitis in Premature Newborns. A Systematic Review of the Literature Campos-Martinez, Ana M. Expósito-Herrera, J. Gonzalez-Bolívar, M. Fernández-Marin, E. Uberos, Jose Front Pediatr Pediatrics Necrotizing enterocolitis (NEC) is a serious condition related to prematurity and the initiation of enteral feeding. In this article, we review the evidence published in recent years on necrotizing enterocolitis risk factors (prematurity, feeding with low-weight formula, existence of intestinal dysbiosis) and protective factors (human milk or donated milk supply, supplementation of human milk with oligosaccharides, probiotics administration, and the determination of disease predictive biomarkers). A systematic review was conducted of preventive, risk and predictive factors for necrotizing enterocolitis in neonates prior to 37 weeks' gestational age, based on a literature search for clinical trials, meta-analyses, randomized controlled trials and systematic reviews published between January 2018 and October 2021. For this purpose, the PubMed, MEDLINE, and Cochrane Library databases were consulted. The literature search obtained 113 articles, of which 19 were selected for further analysis after applying the inclusion and exclusion criteria. The conclusions drawn from this analysis were that adequate knowledge of risk factors that can be prevented or modified (such as alteration of the intestinal microbiota, oxidative stress, metabolic dysfunction at birth, or alteration of the immunity modulation) can reduce the incidence of NEC in premature infants. These factors include the supplementation of enteral nutrition with human milk oligosaccharides (with prebiotic and immunomodulatory effects), the combined administration of probiotics (especially the Lactobacillus spp and Bifidobacterium spp combination, which inhibits bacterial adhesion effects, improves the intestinal mucosa barrier function, strengthens the innate and adaptive immune system and increases the secretion of bioactive metabolites), the supplementation of human milk with lactoferrin and the use of donated milk fortified in accordance with the characteristics of the premature newborn. The determination of factors that can predict the existence of NEC, such as fecal calprotectin, increased TLR4 activity, and IL6 receptor, can lead to an early diagnosis of NEC. Although further studies should be conducted to determine the values of predictive biomarkers of NEC, and/or the recommended doses and strains of probiotics, lactoferrin or oligosaccharides, the knowledge acquired in recent years is encouraging. Frontiers Media S.A. 2022-05-17 /pmc/articles/PMC9152085/ /pubmed/35656377 http://dx.doi.org/10.3389/fped.2022.874976 Text en Copyright © 2022 Campos-Martinez, Expósito-Herrera, Gonzalez-Bolívar, Fernández-Marin and Uberos. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pediatrics
Campos-Martinez, Ana M.
Expósito-Herrera, J.
Gonzalez-Bolívar, M.
Fernández-Marin, E.
Uberos, Jose
Evaluation of Risk and Preventive Factors for Necrotizing Enterocolitis in Premature Newborns. A Systematic Review of the Literature
title Evaluation of Risk and Preventive Factors for Necrotizing Enterocolitis in Premature Newborns. A Systematic Review of the Literature
title_full Evaluation of Risk and Preventive Factors for Necrotizing Enterocolitis in Premature Newborns. A Systematic Review of the Literature
title_fullStr Evaluation of Risk and Preventive Factors for Necrotizing Enterocolitis in Premature Newborns. A Systematic Review of the Literature
title_full_unstemmed Evaluation of Risk and Preventive Factors for Necrotizing Enterocolitis in Premature Newborns. A Systematic Review of the Literature
title_short Evaluation of Risk and Preventive Factors for Necrotizing Enterocolitis in Premature Newborns. A Systematic Review of the Literature
title_sort evaluation of risk and preventive factors for necrotizing enterocolitis in premature newborns. a systematic review of the literature
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9152085/
https://www.ncbi.nlm.nih.gov/pubmed/35656377
http://dx.doi.org/10.3389/fped.2022.874976
work_keys_str_mv AT camposmartinezanam evaluationofriskandpreventivefactorsfornecrotizingenterocolitisinprematurenewbornsasystematicreviewoftheliterature
AT expositoherreraj evaluationofriskandpreventivefactorsfornecrotizingenterocolitisinprematurenewbornsasystematicreviewoftheliterature
AT gonzalezbolivarm evaluationofriskandpreventivefactorsfornecrotizingenterocolitisinprematurenewbornsasystematicreviewoftheliterature
AT fernandezmarine evaluationofriskandpreventivefactorsfornecrotizingenterocolitisinprematurenewbornsasystematicreviewoftheliterature
AT uberosjose evaluationofriskandpreventivefactorsfornecrotizingenterocolitisinprematurenewbornsasystematicreviewoftheliterature