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Sexually Dimorphic Accumulation of Persistent Organic Pollutants in Fetuses
Living in an industrialized era, we are exposed to man-made chemicals including persistent organic pollutants (POPs). Previous studies have shown associations of POP exposure with adverse outcomes in humans, wildlife, and the environment, making it a global concern. Exposure during sensitive windows...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9152108/ https://www.ncbi.nlm.nih.gov/pubmed/35656542 http://dx.doi.org/10.3389/ftox.2022.909307 |
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author | Björvang, Richelle D. Mamsen, Linn Salto |
author_facet | Björvang, Richelle D. Mamsen, Linn Salto |
author_sort | Björvang, Richelle D. |
collection | PubMed |
description | Living in an industrialized era, we are exposed to man-made chemicals including persistent organic pollutants (POPs). Previous studies have shown associations of POP exposure with adverse outcomes in humans, wildlife, and the environment, making it a global concern. Exposure during sensitive windows of susceptibility such as fetal development is of particular concern because of the potential increased risk of developing diseases in childhood and adulthood. However, there are limited studies on the sexual dimorphism of POP accumulation during the prenatal period. In this mini-review, we focus on differences in POP concentrations in the placenta and fetal tissues between males and females. We also show the sexually dimorphic adverse outcomes of prenatal exposure to POPs. Overall, our summary shows that males may accumulate higher concentrations of POPs in the placenta and fetal tissues compared to females, although studies are sparse and inconsistent. In addition, there are differences in adverse health outcomes associated to prenatal POP exposure according to sex. Hence, we highly urge researchers investigating the health effects of POP exposure to consider sexual dimorphism in their studies. |
format | Online Article Text |
id | pubmed-9152108 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-91521082022-06-01 Sexually Dimorphic Accumulation of Persistent Organic Pollutants in Fetuses Björvang, Richelle D. Mamsen, Linn Salto Front Toxicol Toxicology Living in an industrialized era, we are exposed to man-made chemicals including persistent organic pollutants (POPs). Previous studies have shown associations of POP exposure with adverse outcomes in humans, wildlife, and the environment, making it a global concern. Exposure during sensitive windows of susceptibility such as fetal development is of particular concern because of the potential increased risk of developing diseases in childhood and adulthood. However, there are limited studies on the sexual dimorphism of POP accumulation during the prenatal period. In this mini-review, we focus on differences in POP concentrations in the placenta and fetal tissues between males and females. We also show the sexually dimorphic adverse outcomes of prenatal exposure to POPs. Overall, our summary shows that males may accumulate higher concentrations of POPs in the placenta and fetal tissues compared to females, although studies are sparse and inconsistent. In addition, there are differences in adverse health outcomes associated to prenatal POP exposure according to sex. Hence, we highly urge researchers investigating the health effects of POP exposure to consider sexual dimorphism in their studies. Frontiers Media S.A. 2022-05-17 /pmc/articles/PMC9152108/ /pubmed/35656542 http://dx.doi.org/10.3389/ftox.2022.909307 Text en Copyright © 2022 Björvang and Mamsen. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Toxicology Björvang, Richelle D. Mamsen, Linn Salto Sexually Dimorphic Accumulation of Persistent Organic Pollutants in Fetuses |
title | Sexually Dimorphic Accumulation of Persistent Organic Pollutants in Fetuses |
title_full | Sexually Dimorphic Accumulation of Persistent Organic Pollutants in Fetuses |
title_fullStr | Sexually Dimorphic Accumulation of Persistent Organic Pollutants in Fetuses |
title_full_unstemmed | Sexually Dimorphic Accumulation of Persistent Organic Pollutants in Fetuses |
title_short | Sexually Dimorphic Accumulation of Persistent Organic Pollutants in Fetuses |
title_sort | sexually dimorphic accumulation of persistent organic pollutants in fetuses |
topic | Toxicology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9152108/ https://www.ncbi.nlm.nih.gov/pubmed/35656542 http://dx.doi.org/10.3389/ftox.2022.909307 |
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