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Ultrasound-Based Radiomics Can Classify the Etiology of Cervical Lymphadenopathy: A Multi-Center Retrospective Study
Medical diagnostic imaging is essential for the differential diagnosis of cervical lymphadenopathy. Here we develop an ultrasound radiomics method for accurately differentiating cervical lymph node tuberculosis (LNTB), cervical lymphoma, reactive lymph node hyperplasia, and metastatic lymph nodes es...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9152112/ https://www.ncbi.nlm.nih.gov/pubmed/35656511 http://dx.doi.org/10.3389/fonc.2022.856605 |
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author | Liu, Yajing Chen, Jifan Zhang, Chao Li, Qunying Zhou, Hang Zeng, Yiqing Zhang, Ying Li, Jia Xv, Wen Li, Wencun Zhu, Jianing Zhao, Yanan Chen, Qin Huang, Yi Li, Hongming Huang, Ying Yang, Gaoyi Huang, Pintong |
author_facet | Liu, Yajing Chen, Jifan Zhang, Chao Li, Qunying Zhou, Hang Zeng, Yiqing Zhang, Ying Li, Jia Xv, Wen Li, Wencun Zhu, Jianing Zhao, Yanan Chen, Qin Huang, Yi Li, Hongming Huang, Ying Yang, Gaoyi Huang, Pintong |
author_sort | Liu, Yajing |
collection | PubMed |
description | Medical diagnostic imaging is essential for the differential diagnosis of cervical lymphadenopathy. Here we develop an ultrasound radiomics method for accurately differentiating cervical lymph node tuberculosis (LNTB), cervical lymphoma, reactive lymph node hyperplasia, and metastatic lymph nodes especially in the multi-operator, cross-machine, multicenter context. The inter-observer and intra-observer consistency of radiomics parameters from the region of interest were 0.8245 and 0.9228, respectively. The radiomics model showed good and repeatable diagnostic performance for multiple classification diagnosis of cervical lymphadenopathy, especially in LNTB (area under the curve, AUC: 0.673, 0.662, and 0.626) and cervical lymphoma (AUC: 0.623, 0.644, and 0.602) in the whole set, training set, and test set, respectively. However, the diagnostic performance of lymphadenopathy among skilled radiologists was varied (Kappa coefficient: 0.108, *p < 0.001). The diagnostic performance of radiomics is comparable and more reproducible compared with those of skilled radiologists. Our study offers a more comprehensive method for differentiating LNTB, cervical lymphoma, reactive lymph node hyperplasia, and metastatic LN. |
format | Online Article Text |
id | pubmed-9152112 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-91521122022-06-01 Ultrasound-Based Radiomics Can Classify the Etiology of Cervical Lymphadenopathy: A Multi-Center Retrospective Study Liu, Yajing Chen, Jifan Zhang, Chao Li, Qunying Zhou, Hang Zeng, Yiqing Zhang, Ying Li, Jia Xv, Wen Li, Wencun Zhu, Jianing Zhao, Yanan Chen, Qin Huang, Yi Li, Hongming Huang, Ying Yang, Gaoyi Huang, Pintong Front Oncol Oncology Medical diagnostic imaging is essential for the differential diagnosis of cervical lymphadenopathy. Here we develop an ultrasound radiomics method for accurately differentiating cervical lymph node tuberculosis (LNTB), cervical lymphoma, reactive lymph node hyperplasia, and metastatic lymph nodes especially in the multi-operator, cross-machine, multicenter context. The inter-observer and intra-observer consistency of radiomics parameters from the region of interest were 0.8245 and 0.9228, respectively. The radiomics model showed good and repeatable diagnostic performance for multiple classification diagnosis of cervical lymphadenopathy, especially in LNTB (area under the curve, AUC: 0.673, 0.662, and 0.626) and cervical lymphoma (AUC: 0.623, 0.644, and 0.602) in the whole set, training set, and test set, respectively. However, the diagnostic performance of lymphadenopathy among skilled radiologists was varied (Kappa coefficient: 0.108, *p < 0.001). The diagnostic performance of radiomics is comparable and more reproducible compared with those of skilled radiologists. Our study offers a more comprehensive method for differentiating LNTB, cervical lymphoma, reactive lymph node hyperplasia, and metastatic LN. Frontiers Media S.A. 2022-05-17 /pmc/articles/PMC9152112/ /pubmed/35656511 http://dx.doi.org/10.3389/fonc.2022.856605 Text en Copyright © 2022 Liu, Chen, Zhang, Li, Zhou, Zeng, Zhang, Li, Xv, Li, Zhu, Zhao, Chen, Huang, Li, Huang, Yang and Huang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Liu, Yajing Chen, Jifan Zhang, Chao Li, Qunying Zhou, Hang Zeng, Yiqing Zhang, Ying Li, Jia Xv, Wen Li, Wencun Zhu, Jianing Zhao, Yanan Chen, Qin Huang, Yi Li, Hongming Huang, Ying Yang, Gaoyi Huang, Pintong Ultrasound-Based Radiomics Can Classify the Etiology of Cervical Lymphadenopathy: A Multi-Center Retrospective Study |
title | Ultrasound-Based Radiomics Can Classify the Etiology of Cervical Lymphadenopathy: A Multi-Center Retrospective Study |
title_full | Ultrasound-Based Radiomics Can Classify the Etiology of Cervical Lymphadenopathy: A Multi-Center Retrospective Study |
title_fullStr | Ultrasound-Based Radiomics Can Classify the Etiology of Cervical Lymphadenopathy: A Multi-Center Retrospective Study |
title_full_unstemmed | Ultrasound-Based Radiomics Can Classify the Etiology of Cervical Lymphadenopathy: A Multi-Center Retrospective Study |
title_short | Ultrasound-Based Radiomics Can Classify the Etiology of Cervical Lymphadenopathy: A Multi-Center Retrospective Study |
title_sort | ultrasound-based radiomics can classify the etiology of cervical lymphadenopathy: a multi-center retrospective study |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9152112/ https://www.ncbi.nlm.nih.gov/pubmed/35656511 http://dx.doi.org/10.3389/fonc.2022.856605 |
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