Cargando…

Resibufogenin Targets the ATP1A1 Signaling Cascade to Induce G2/M Phase Arrest and Inhibit Invasion in Glioma

Resibufogenin (RB) is a major active ingredient in the traditional Chinese medicine Chansu and has garnered considerable attention for its efficacy in the treatment of cancer. However, the anticancer effects and underlying mechanisms of RB on glioblastoma (GBM) remain unknown. Here, we found that RB...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Xun, Yao, Zhong, Xue, Zhiyi, Wang, Shuai, Liu, Xuemeng, Hu, Yaotian, Zhang, Yan, Wang, Jian, Li, Xingang, Chen, Anjing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9152115/ https://www.ncbi.nlm.nih.gov/pubmed/35656311 http://dx.doi.org/10.3389/fphar.2022.855626

Ejemplares similares

Resibufogenin Suppresses Triple-Negative Breast Cancer Angiogenesis by Blocking VEGFR2-Mediated Signaling Pathway
por: Yang, Ting, et al.
Publicado: (2021)

Resibufogenin Induces G1-Phase Arrest through the Proteasomal Degradation of Cyclin D1 in Human Malignant Tumor Cells
por: Ichikawa, Masami, et al.
Publicado: (2015)

Valtrate, an iridoid compound in Valeriana, elicits anti-glioblastoma activity through inhibition of the PDGFRA/MEK/ERK signaling pathway
por: Liu, Xuemeng, et al.
Publicado: (2023)

Resibufogenin and Cinobufagin Activate Central Neurons through an Ouabain-Like Action
por: Wang, Ze-Jun, et al.
Publicado: (2014)

Antipsychotic Drug Trifluoperazine Suppresses Colorectal Cancer by Inducing G0/G1 Arrest and Apoptosis
por: Xia, Yong, et al.
Publicado: (2019)

Resibufogenin suppresses colorectal cancer growth and metastasis through RIP3-mediated necroptosis
por: Han, Qinrui, et al.
Publicado: (2018)

TRIM56 promotes malignant progression of glioblastoma by stabilizing cIAP1 protein
por: Yang, Xu, et al.
Publicado: (2022)

Research Progress About Glioma Stem Cells in the Immune Microenvironment of Glioma
por: Li, Xiangyu, et al.
Publicado: (2021)

Honokiol Induces Apoptosis, G1 Arrest, and Autophagy in KRAS Mutant Lung Cancer Cells
por: Luo, Lian-Xiang, et al.
Publicado: (2017)

Promising galactose-decorated biodegradable poloxamer 188-PLGA diblock copolymer nanoparticles of resibufogenin for enhancing liver cancer therapy
por: Dong, Hao, et al.
Publicado: (2017)

Glucocappasalin Induces G2/M-Phase Arrest, Apoptosis, and Autophagy Pathways by Targeting CDK1 and PLK1 in Cervical Carcinoma Cells
por: Xu, Guangya, et al.
Publicado: (2021)

T-Cell Exhaustion Status Under High and Low Levels of Hypoxia-Inducible Factor 1α Expression in Glioma
por: Liu, Shuai, et al.
Publicado: (2021)

Niclosamide Induces Cell Cycle Arrest in G1 Phase in Head and Neck Squamous Cell Carcinoma Through Let-7d/CDC34 Axis
por: Han, Zewen, et al.
Publicado: (2019)

PDGFA/PDGFRα-regulated GOLM1 promotes human glioma progression through activation of AKT
por: Xu, Ran, et al.
Publicado: (2017)

A Betulinic Acid Derivative, BA5, Induces G0/G1 Cell Arrest, Apoptosis Like-Death, and Morphological Alterations in Leishmania sp
por: Magalhães, Tatiana Barbosa dos Santos, et al.
Publicado: (2022)

Peiminine Induces G0/G1-Phase Arrest, Apoptosis, and Autophagy via the ROS/JNK Signaling Pathway in Human Osteosarcoma Cells in Vitro and in Vivo
por: Yu, Lei, et al.
Publicado: (2021)

Silibinin Induces G2/M Cell Cycle Arrest by Activating Drp1-Dependent Mitochondrial Fission in Cervical Cancer
por: You, Yanting, et al.
Publicado: (2020)

Prognostic value and immune-infiltration pattern of FOXD3-AS1 in patients with glioma
por: Chen, Zhenhua, et al.
Publicado: (2023)

Downregulation of ATP1A1 Expression by Panax notoginseng (Burk.) F.H. Chen Saponins: A Potential Mechanism of Antitumor Effects in HepG2 Cells and In Vivo
por: Feng, Xiao-Yi, et al.
Publicado: (2021)

Resibufogenin inhibits the malignant characteristics of multiple myeloma cells by blocking the PI3K/Akt signaling pathway
por: Zhou, Yan, et al.
Publicado: (2022)

CBX7 is a glioma prognostic marker and induces G1/S arrest via the silencing of CCNE1
por: Yu, Tianfu, et al.
Publicado: (2017)

Obg-Like ATPase 1 Enhances Chemoresistance of Breast Cancer via Activation of TGF-β/Smad Axis Cascades
por: Liu, Jianzhou, et al.
Publicado: (2020)

Repeated Aconitine Treatment Induced the Remodeling of Mitochondrial Function via AMPK–OPA1–ATP5A1 Pathway
por: Qiu, Li-Zhen, et al.
Publicado: (2021)

Shortage of Cellular ATP as a Cause of Diseases and Strategies to Enhance ATP
por: Johnson, Todd A., et al.
Publicado: (2019)

Enhancement of Dissolving Capacity and Reducing Gastric Mucosa Irritation by Complex Formation of Resibufogenin with β-Cyclodextrin or 2-Hydroxypropyl-β-cyclodextrin
por: Liu, Nan, et al.
Publicado: (2022)

Coiled-coil domain containing 109B is a HIF1α-regulated gene critical for progression of human gliomas
por: Xu, Ran, et al.
Publicado: (2017)

Alkylaminophenol Induces G1/S Phase Cell Cycle Arrest in Glioblastoma Cells Through p53 and Cyclin-Dependent Kinase Signaling Pathway
por: Doan, Phuong, et al.
Publicado: (2019)

CCT020312 Inhibits Triple-Negative Breast Cancer Through PERK Pathway-Mediated G1 Phase Cell Cycle Arrest and Apoptosis
por: Li, Xiaoli, et al.
Publicado: (2020)

Targeting the splicing factor NONO inhibits GBM progression through GPX1 intron retention
por: Wang, Xu, et al.
Publicado: (2022)

Multi-omics analysis reveals CLIC1 as a therapeutic vulnerability of gliomas
por: Wang, Chengcheng, et al.
Publicado: (2023)

Moxidectin inhibits glioma cell viability by inducing G0/G1 cell cycle arrest and apoptosis
por: Song, Dandan, et al.
Publicado: (2018)

CL-705G: a novel chemical Kir6.2-specific K(ATP) channel opener
por: Gando, Ivan, et al.
Publicado: (2023)

Research on prescribing cascades: a scoping review
por: Chen, Zhe, et al.
Publicado: (2023)

Cinnamomi ramulus inhibits cancer cells growth by inducing G2/M arrest
por: Li, Jing, et al.
Publicado: (2023)

Omeprazole Inhibits Cell Proliferation and Induces G0/G1 Cell Cycle Arrest through Up-regulating miR-203a-3p Expression in Barrett’s Esophagus Cells
por: Hou, Yichao, et al.
Publicado: (2018)

The Prognostic and Therapeutic Value of PD-L1 in Glioma
por: Chen, Ruo Qiao, et al.
Publicado: (2019)

Eupatilin inhibits glioma proliferation, migration, and invasion by arresting cell cycle at G1/S phase and disrupting the cytoskeletal structure
por: Fei, Xiaowei, et al.
Publicado: (2019)

Piperine Suppresses Pyroptosis and Interleukin-1β Release upon ATP Triggering and Bacterial Infection
por: Liang, Yi-Dan, et al.
Publicado: (2016)

Pharmacogenetic Aspects of the Interaction of AT1 Receptor Antagonists With ATP-Binding Cassette Transporter ABCG2
por: Ripperger, Anne, et al.
Publicado: (2018)

Haploinsufficient TNAP Mice Display Decreased Extracellular ATP Levels and Expression of Pannexin-1 Channels
por: Sebastián-Serrano, Álvaro, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_958ntdkhvt9s9meo660fgu1osa