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Emerging Roles of Non-Coding RNAs in Childhood Asthma

Asthma is a chronic airway inflammatory disease in children characterized by airway inflammation, airway hyperresponsiveness and airway remodeling. Childhood asthma is usually associated with allergy and atopy, unlike adult asthma, which is commonly associated with obesity, smoking, etc. The pathoge...

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Autores principales: Liang, Juan, Liu, Xiao-Hua, Chen, Xue-Mei, Song, Xiu-Ling, Li, Wen, Huang, Yuge
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9152219/
https://www.ncbi.nlm.nih.gov/pubmed/35656293
http://dx.doi.org/10.3389/fphar.2022.856104
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author Liang, Juan
Liu, Xiao-Hua
Chen, Xue-Mei
Song, Xiu-Ling
Li, Wen
Huang, Yuge
author_facet Liang, Juan
Liu, Xiao-Hua
Chen, Xue-Mei
Song, Xiu-Ling
Li, Wen
Huang, Yuge
author_sort Liang, Juan
collection PubMed
description Asthma is a chronic airway inflammatory disease in children characterized by airway inflammation, airway hyperresponsiveness and airway remodeling. Childhood asthma is usually associated with allergy and atopy, unlike adult asthma, which is commonly associated with obesity, smoking, etc. The pathogenesis and diagnosis of childhood asthma also remains more challenging than adult asthma, such as many diseases showing similar symptoms may coexist and be confused with asthma. In terms of the treatment, although most childhood asthma can potentially be self-managed and controlled with drugs, approximately 5–10% of children suffer from severe uncontrolled asthma, which carries significant health and socioeconomic burdens. Therefore, it is necessary to explore the pathogenesis of childhood asthma from a new perspective. Studies have revealed that non-coding RNAs (ncRNAs) are involved in the regulation of respiratory diseases. In addition, altered expression of ncRNAs in blood, and in condensate of sputum or exhalation affects the progression of asthma via regulating immune response. In this review, we outline the regulation and pathogenesis of asthma and summarize the role of ncRNAs in childhood asthma. We also hold promise that ncRNAs may be used for the development of biomarkers and support a new therapeutic strategy for childhood asthma.
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spelling pubmed-91522192022-06-01 Emerging Roles of Non-Coding RNAs in Childhood Asthma Liang, Juan Liu, Xiao-Hua Chen, Xue-Mei Song, Xiu-Ling Li, Wen Huang, Yuge Front Pharmacol Pharmacology Asthma is a chronic airway inflammatory disease in children characterized by airway inflammation, airway hyperresponsiveness and airway remodeling. Childhood asthma is usually associated with allergy and atopy, unlike adult asthma, which is commonly associated with obesity, smoking, etc. The pathogenesis and diagnosis of childhood asthma also remains more challenging than adult asthma, such as many diseases showing similar symptoms may coexist and be confused with asthma. In terms of the treatment, although most childhood asthma can potentially be self-managed and controlled with drugs, approximately 5–10% of children suffer from severe uncontrolled asthma, which carries significant health and socioeconomic burdens. Therefore, it is necessary to explore the pathogenesis of childhood asthma from a new perspective. Studies have revealed that non-coding RNAs (ncRNAs) are involved in the regulation of respiratory diseases. In addition, altered expression of ncRNAs in blood, and in condensate of sputum or exhalation affects the progression of asthma via regulating immune response. In this review, we outline the regulation and pathogenesis of asthma and summarize the role of ncRNAs in childhood asthma. We also hold promise that ncRNAs may be used for the development of biomarkers and support a new therapeutic strategy for childhood asthma. Frontiers Media S.A. 2022-05-17 /pmc/articles/PMC9152219/ /pubmed/35656293 http://dx.doi.org/10.3389/fphar.2022.856104 Text en Copyright © 2022 Liang, Liu, Chen, Song, Li and Huang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Liang, Juan
Liu, Xiao-Hua
Chen, Xue-Mei
Song, Xiu-Ling
Li, Wen
Huang, Yuge
Emerging Roles of Non-Coding RNAs in Childhood Asthma
title Emerging Roles of Non-Coding RNAs in Childhood Asthma
title_full Emerging Roles of Non-Coding RNAs in Childhood Asthma
title_fullStr Emerging Roles of Non-Coding RNAs in Childhood Asthma
title_full_unstemmed Emerging Roles of Non-Coding RNAs in Childhood Asthma
title_short Emerging Roles of Non-Coding RNAs in Childhood Asthma
title_sort emerging roles of non-coding rnas in childhood asthma
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9152219/
https://www.ncbi.nlm.nih.gov/pubmed/35656293
http://dx.doi.org/10.3389/fphar.2022.856104
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