Cargando…

Chronic Cold Exposure Leads to Daytime Preference in the Circadian Expression of Hepatic Metabolic Genes

Circadian control allows organisms to anticipate and adapt to environmental changes through changes in physiology and behavior. The circadian system timing is entrained by cues, such as light, food, and temperature. An ambient temperature dramatically impacts the sleep–wake cycle and metabolic rhyth...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Zhida, Cheng, Le, Ma, Junxian, Wang, Xiaomei, Zhao, Yingying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9152247/
https://www.ncbi.nlm.nih.gov/pubmed/35655959
http://dx.doi.org/10.3389/fphys.2022.865627
_version_ 1784717604534878208
author Zhang, Zhida
Cheng, Le
Ma, Junxian
Wang, Xiaomei
Zhao, Yingying
author_facet Zhang, Zhida
Cheng, Le
Ma, Junxian
Wang, Xiaomei
Zhao, Yingying
author_sort Zhang, Zhida
collection PubMed
description Circadian control allows organisms to anticipate and adapt to environmental changes through changes in physiology and behavior. The circadian system timing is entrained by cues, such as light, food, and temperature. An ambient temperature dramatically impacts the sleep–wake cycle and metabolic rhythmicity. As endotherms, mammals rely on tissues such as the liver to provide fuel for thermogenesis to maintain body temperature. The adaptive response of the circadian rhythm of liver metabolism to chronic cold exposure remains largely unexplored. Here, we investigated the circadian rhythm adaptation of hepatic metabolism in response to environmental cold stress using a mouse model of chronic cold exposure. We analyzed metabolites and transcripts of mouse livers at 24 h and found that long-term low-temperature exposure resulted in a synergistic and phase synchronization of transcriptional rhythms of many genes associated with metabolic pathways. Notably, transcription peaked in the early light phase when the body temperature was relatively low. Our results suggest that chronic cold does not alter the rhythmic expression of essential core clock genes in the liver, so the rewiring of clock control gene expression is another mechanism that optimizes the circadian rhythm of liver metabolism to meet the energy requirements of animal thermogenesis.
format Online
Article
Text
id pubmed-9152247
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-91522472022-06-01 Chronic Cold Exposure Leads to Daytime Preference in the Circadian Expression of Hepatic Metabolic Genes Zhang, Zhida Cheng, Le Ma, Junxian Wang, Xiaomei Zhao, Yingying Front Physiol Physiology Circadian control allows organisms to anticipate and adapt to environmental changes through changes in physiology and behavior. The circadian system timing is entrained by cues, such as light, food, and temperature. An ambient temperature dramatically impacts the sleep–wake cycle and metabolic rhythmicity. As endotherms, mammals rely on tissues such as the liver to provide fuel for thermogenesis to maintain body temperature. The adaptive response of the circadian rhythm of liver metabolism to chronic cold exposure remains largely unexplored. Here, we investigated the circadian rhythm adaptation of hepatic metabolism in response to environmental cold stress using a mouse model of chronic cold exposure. We analyzed metabolites and transcripts of mouse livers at 24 h and found that long-term low-temperature exposure resulted in a synergistic and phase synchronization of transcriptional rhythms of many genes associated with metabolic pathways. Notably, transcription peaked in the early light phase when the body temperature was relatively low. Our results suggest that chronic cold does not alter the rhythmic expression of essential core clock genes in the liver, so the rewiring of clock control gene expression is another mechanism that optimizes the circadian rhythm of liver metabolism to meet the energy requirements of animal thermogenesis. Frontiers Media S.A. 2022-05-17 /pmc/articles/PMC9152247/ /pubmed/35655959 http://dx.doi.org/10.3389/fphys.2022.865627 Text en Copyright © 2022 Zhang, Cheng, Ma, Wang and Zhao. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Zhang, Zhida
Cheng, Le
Ma, Junxian
Wang, Xiaomei
Zhao, Yingying
Chronic Cold Exposure Leads to Daytime Preference in the Circadian Expression of Hepatic Metabolic Genes
title Chronic Cold Exposure Leads to Daytime Preference in the Circadian Expression of Hepatic Metabolic Genes
title_full Chronic Cold Exposure Leads to Daytime Preference in the Circadian Expression of Hepatic Metabolic Genes
title_fullStr Chronic Cold Exposure Leads to Daytime Preference in the Circadian Expression of Hepatic Metabolic Genes
title_full_unstemmed Chronic Cold Exposure Leads to Daytime Preference in the Circadian Expression of Hepatic Metabolic Genes
title_short Chronic Cold Exposure Leads to Daytime Preference in the Circadian Expression of Hepatic Metabolic Genes
title_sort chronic cold exposure leads to daytime preference in the circadian expression of hepatic metabolic genes
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9152247/
https://www.ncbi.nlm.nih.gov/pubmed/35655959
http://dx.doi.org/10.3389/fphys.2022.865627
work_keys_str_mv AT zhangzhida chroniccoldexposureleadstodaytimepreferenceinthecircadianexpressionofhepaticmetabolicgenes
AT chengle chroniccoldexposureleadstodaytimepreferenceinthecircadianexpressionofhepaticmetabolicgenes
AT majunxian chroniccoldexposureleadstodaytimepreferenceinthecircadianexpressionofhepaticmetabolicgenes
AT wangxiaomei chroniccoldexposureleadstodaytimepreferenceinthecircadianexpressionofhepaticmetabolicgenes
AT zhaoyingying chroniccoldexposureleadstodaytimepreferenceinthecircadianexpressionofhepaticmetabolicgenes