New Sesquiterpenoids From Plant-Associated Irpex lacteus

Bacteria produce a large number of virulence factors through the quorum sensing (QS) mechanism. Inhibiting such QS system of the pathogens without disturbing their growth is a potential strategy to control multi-drug-resistant pathogens. To accomplish this, two new tremulane-type sesquiterpenoids, i...

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Autores principales: Luo, Huai-Zhi, Jiang, Huan, Huang, Xi-Shan, Jia, Ai-Qun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9152251/
https://www.ncbi.nlm.nih.gov/pubmed/35655702
http://dx.doi.org/10.3389/fchem.2022.905108
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author Luo, Huai-Zhi
Jiang, Huan
Huang, Xi-Shan
Jia, Ai-Qun
author_facet Luo, Huai-Zhi
Jiang, Huan
Huang, Xi-Shan
Jia, Ai-Qun
author_sort Luo, Huai-Zhi
collection PubMed
description Bacteria produce a large number of virulence factors through the quorum sensing (QS) mechanism. Inhibiting such QS system of the pathogens without disturbing their growth is a potential strategy to control multi-drug-resistant pathogens. To accomplish this, two new tremulane-type sesquiterpenoids, irpexolaceus H (1) and I (2), along with two known furan compounds, irpexlacte B (3) and C (4), were isolated from Orychophragmus violaceus (L.) OE Schulz endophytic fungus Irpex lacteus (Fr.) Fr. Their structures were elucidated by detailed spectroscopic data (NMR, HRESIMS, IR, and UV), single-crystal X-ray diffraction, and electronic circular dichroism (ECD) analysis. Furthermore, those compounds were evaluated for anti-quorum sensing (anti-QS) activity, and compound 3 was found contributing to the potential QS inhibitory activity.
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spelling pubmed-91522512022-06-01 New Sesquiterpenoids From Plant-Associated Irpex lacteus Luo, Huai-Zhi Jiang, Huan Huang, Xi-Shan Jia, Ai-Qun Front Chem Chemistry Bacteria produce a large number of virulence factors through the quorum sensing (QS) mechanism. Inhibiting such QS system of the pathogens without disturbing their growth is a potential strategy to control multi-drug-resistant pathogens. To accomplish this, two new tremulane-type sesquiterpenoids, irpexolaceus H (1) and I (2), along with two known furan compounds, irpexlacte B (3) and C (4), were isolated from Orychophragmus violaceus (L.) OE Schulz endophytic fungus Irpex lacteus (Fr.) Fr. Their structures were elucidated by detailed spectroscopic data (NMR, HRESIMS, IR, and UV), single-crystal X-ray diffraction, and electronic circular dichroism (ECD) analysis. Furthermore, those compounds were evaluated for anti-quorum sensing (anti-QS) activity, and compound 3 was found contributing to the potential QS inhibitory activity. Frontiers Media S.A. 2022-05-17 /pmc/articles/PMC9152251/ /pubmed/35655702 http://dx.doi.org/10.3389/fchem.2022.905108 Text en Copyright © 2022 Luo, Jiang, Huang and Jia. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Chemistry
Luo, Huai-Zhi
Jiang, Huan
Huang, Xi-Shan
Jia, Ai-Qun
New Sesquiterpenoids From Plant-Associated Irpex lacteus
title New Sesquiterpenoids From Plant-Associated Irpex lacteus
title_full New Sesquiterpenoids From Plant-Associated Irpex lacteus
title_fullStr New Sesquiterpenoids From Plant-Associated Irpex lacteus
title_full_unstemmed New Sesquiterpenoids From Plant-Associated Irpex lacteus
title_short New Sesquiterpenoids From Plant-Associated Irpex lacteus
title_sort new sesquiterpenoids from plant-associated irpex lacteus
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9152251/
https://www.ncbi.nlm.nih.gov/pubmed/35655702
http://dx.doi.org/10.3389/fchem.2022.905108
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