Structural and biochemical mechanism for increased infectivity and immune evasion of Omicron BA.2 variant compared to BA.1 and their possible mouse origins

The Omicron BA.2 variant has become a dominant infective strain worldwide. Receptor binding studies show that the Omicron BA.2 spike trimer exhibits 11-fold and 2-fold higher potency in binding to human ACE2 than the spike trimer from the wildtype (WT) and Omicron BA.1 strains. The structure of the...

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Detalles Bibliográficos
Autores principales: Xu, Youwei, Wu, Canrong, Cao, Xiaodan, Gu, Chunyin, Liu, Heng, Jiang, Mengting, Wang, Xiaoxi, Yuan, Qingning, Wu, Kai, Liu, Jia, Wang, Deyi, He, Xianqing, Wang, Xueping, Deng, Su-Jun, Xu, H. Eric, Yin, Wanchao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9152305/
https://www.ncbi.nlm.nih.gov/pubmed/35641567
http://dx.doi.org/10.1038/s41422-022-00672-4

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