Morus alba L. for Blood Sugar Management: A Systematic Review and Meta-Analysis

INTRODUCTION: Morus alba L. is used for blood sugar management in patients with diabetes mellitus. This review aimed to evaluate the effect of Morus alba on blood sugar management. METHODS: This review was conducted in accordance with the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P). We searched PubMed, EMBASE, and four Korean medical databases (RISS, OASIS, NDSL, and KISS) using relevant keywords. Randomized controlled trials with any type of control intervention were included. The selection of studies, data extraction, and quality assessment were performed independently by two researchers. RESULTS: Our results showed that Morus alba can reduce postprandial glucose and insulin levels. However, it is insufficient to conclude that Morus alba is an effective intervention for lowering blood glucose levels. Therefore, more rigorous studies are needed to reveal the effect of MA on blood glucose levels. CONCLUSION: The conclusion of this review provides evidence that Morus alba can control blood sugar level. This systematic review was registered with the International Prospective Register of Systematic Reviews (PROSPERO) (CRD42021255940).