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Roles and Mechanisms of Regulated Necrosis in Corneal Diseases: Progress and Perspectives
Regulated necrosis is defined as cell death characterized by loss of the cell membrane integrity and release of the cytoplasmic content. It contributes to the development and progression of some diseases, including ischemic stroke injury, liver diseases, hypertension, and cancer. Various forms of re...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9152437/ https://www.ncbi.nlm.nih.gov/pubmed/35655803 http://dx.doi.org/10.1155/2022/2695212 |
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author | Lin, Wanying Chen, Minting Cissé, Yacouba Chen, Xiaofeng Bai, Lang |
author_facet | Lin, Wanying Chen, Minting Cissé, Yacouba Chen, Xiaofeng Bai, Lang |
author_sort | Lin, Wanying |
collection | PubMed |
description | Regulated necrosis is defined as cell death characterized by loss of the cell membrane integrity and release of the cytoplasmic content. It contributes to the development and progression of some diseases, including ischemic stroke injury, liver diseases, hypertension, and cancer. Various forms of regulated necrosis, particularly pyroptosis, necroptosis, and ferroptosis, have been implicated in the pathogenesis of corneal disease. Regulated necrosis of corneal cells enhances inflammatory reactions in the adjacent corneal tissues, leading to recurrence and aggravation of corneal disease. In this review, we summarize the molecular mechanisms of pyroptosis, necroptosis, and ferroptosis in corneal diseases and discuss the roles of regulated necrosis in inflammation regulation, tissue repair, and corneal disease outcomes. |
format | Online Article Text |
id | pubmed-9152437 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-91524372022-06-01 Roles and Mechanisms of Regulated Necrosis in Corneal Diseases: Progress and Perspectives Lin, Wanying Chen, Minting Cissé, Yacouba Chen, Xiaofeng Bai, Lang J Ophthalmol Review Article Regulated necrosis is defined as cell death characterized by loss of the cell membrane integrity and release of the cytoplasmic content. It contributes to the development and progression of some diseases, including ischemic stroke injury, liver diseases, hypertension, and cancer. Various forms of regulated necrosis, particularly pyroptosis, necroptosis, and ferroptosis, have been implicated in the pathogenesis of corneal disease. Regulated necrosis of corneal cells enhances inflammatory reactions in the adjacent corneal tissues, leading to recurrence and aggravation of corneal disease. In this review, we summarize the molecular mechanisms of pyroptosis, necroptosis, and ferroptosis in corneal diseases and discuss the roles of regulated necrosis in inflammation regulation, tissue repair, and corneal disease outcomes. Hindawi 2022-05-23 /pmc/articles/PMC9152437/ /pubmed/35655803 http://dx.doi.org/10.1155/2022/2695212 Text en Copyright © 2022 Wanying Lin et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Lin, Wanying Chen, Minting Cissé, Yacouba Chen, Xiaofeng Bai, Lang Roles and Mechanisms of Regulated Necrosis in Corneal Diseases: Progress and Perspectives |
title | Roles and Mechanisms of Regulated Necrosis in Corneal Diseases: Progress and Perspectives |
title_full | Roles and Mechanisms of Regulated Necrosis in Corneal Diseases: Progress and Perspectives |
title_fullStr | Roles and Mechanisms of Regulated Necrosis in Corneal Diseases: Progress and Perspectives |
title_full_unstemmed | Roles and Mechanisms of Regulated Necrosis in Corneal Diseases: Progress and Perspectives |
title_short | Roles and Mechanisms of Regulated Necrosis in Corneal Diseases: Progress and Perspectives |
title_sort | roles and mechanisms of regulated necrosis in corneal diseases: progress and perspectives |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9152437/ https://www.ncbi.nlm.nih.gov/pubmed/35655803 http://dx.doi.org/10.1155/2022/2695212 |
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