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Roles and Mechanisms of Regulated Necrosis in Corneal Diseases: Progress and Perspectives

Regulated necrosis is defined as cell death characterized by loss of the cell membrane integrity and release of the cytoplasmic content. It contributes to the development and progression of some diseases, including ischemic stroke injury, liver diseases, hypertension, and cancer. Various forms of re...

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Detalles Bibliográficos
Autores principales: Lin, Wanying, Chen, Minting, Cissé, Yacouba, Chen, Xiaofeng, Bai, Lang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9152437/
https://www.ncbi.nlm.nih.gov/pubmed/35655803
http://dx.doi.org/10.1155/2022/2695212
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author Lin, Wanying
Chen, Minting
Cissé, Yacouba
Chen, Xiaofeng
Bai, Lang
author_facet Lin, Wanying
Chen, Minting
Cissé, Yacouba
Chen, Xiaofeng
Bai, Lang
author_sort Lin, Wanying
collection PubMed
description Regulated necrosis is defined as cell death characterized by loss of the cell membrane integrity and release of the cytoplasmic content. It contributes to the development and progression of some diseases, including ischemic stroke injury, liver diseases, hypertension, and cancer. Various forms of regulated necrosis, particularly pyroptosis, necroptosis, and ferroptosis, have been implicated in the pathogenesis of corneal disease. Regulated necrosis of corneal cells enhances inflammatory reactions in the adjacent corneal tissues, leading to recurrence and aggravation of corneal disease. In this review, we summarize the molecular mechanisms of pyroptosis, necroptosis, and ferroptosis in corneal diseases and discuss the roles of regulated necrosis in inflammation regulation, tissue repair, and corneal disease outcomes.
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spelling pubmed-91524372022-06-01 Roles and Mechanisms of Regulated Necrosis in Corneal Diseases: Progress and Perspectives Lin, Wanying Chen, Minting Cissé, Yacouba Chen, Xiaofeng Bai, Lang J Ophthalmol Review Article Regulated necrosis is defined as cell death characterized by loss of the cell membrane integrity and release of the cytoplasmic content. It contributes to the development and progression of some diseases, including ischemic stroke injury, liver diseases, hypertension, and cancer. Various forms of regulated necrosis, particularly pyroptosis, necroptosis, and ferroptosis, have been implicated in the pathogenesis of corneal disease. Regulated necrosis of corneal cells enhances inflammatory reactions in the adjacent corneal tissues, leading to recurrence and aggravation of corneal disease. In this review, we summarize the molecular mechanisms of pyroptosis, necroptosis, and ferroptosis in corneal diseases and discuss the roles of regulated necrosis in inflammation regulation, tissue repair, and corneal disease outcomes. Hindawi 2022-05-23 /pmc/articles/PMC9152437/ /pubmed/35655803 http://dx.doi.org/10.1155/2022/2695212 Text en Copyright © 2022 Wanying Lin et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Lin, Wanying
Chen, Minting
Cissé, Yacouba
Chen, Xiaofeng
Bai, Lang
Roles and Mechanisms of Regulated Necrosis in Corneal Diseases: Progress and Perspectives
title Roles and Mechanisms of Regulated Necrosis in Corneal Diseases: Progress and Perspectives
title_full Roles and Mechanisms of Regulated Necrosis in Corneal Diseases: Progress and Perspectives
title_fullStr Roles and Mechanisms of Regulated Necrosis in Corneal Diseases: Progress and Perspectives
title_full_unstemmed Roles and Mechanisms of Regulated Necrosis in Corneal Diseases: Progress and Perspectives
title_short Roles and Mechanisms of Regulated Necrosis in Corneal Diseases: Progress and Perspectives
title_sort roles and mechanisms of regulated necrosis in corneal diseases: progress and perspectives
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9152437/
https://www.ncbi.nlm.nih.gov/pubmed/35655803
http://dx.doi.org/10.1155/2022/2695212
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