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Endoplasmin regulates differentiation of tonsil-derived mesenchymal stem cells into chondrocytes through ERK signaling

It is well-known that some species of lizard have an exceptional ability known as caudal autotomy (voluntary self-amputation of the tail) as an anti-predation mechanism. After amputation occurs, they can regenerate their new tails in a few days. The new tail section is generally shorter than the ori...

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Autores principales: Kim, Hye Ryeong, Choi, Hyeongrok, Park, Soon Yong, Song, Young-Chul, Kim, Jae-Ho, Shim, Sangin, Jun, Woojin, Kim, Kyung-Jin, Han, Jin, Chi, Seung-Wook, Leem, Sun-Hee, Chung, Jin Woong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Biochemistry and Molecular Biology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9152576/
https://www.ncbi.nlm.nih.gov/pubmed/35168699
http://dx.doi.org/10.5483/BMBRep.2022.55.5.173
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author Kim, Hye Ryeong
Choi, Hyeongrok
Park, Soon Yong
Song, Young-Chul
Kim, Jae-Ho
Shim, Sangin
Jun, Woojin
Kim, Kyung-Jin
Han, Jin
Chi, Seung-Wook
Leem, Sun-Hee
Chung, Jin Woong
author_facet Kim, Hye Ryeong
Choi, Hyeongrok
Park, Soon Yong
Song, Young-Chul
Kim, Jae-Ho
Shim, Sangin
Jun, Woojin
Kim, Kyung-Jin
Han, Jin
Chi, Seung-Wook
Leem, Sun-Hee
Chung, Jin Woong
author_sort Kim, Hye Ryeong
collection PubMed
description It is well-known that some species of lizard have an exceptional ability known as caudal autotomy (voluntary self-amputation of the tail) as an anti-predation mechanism. After amputation occurs, they can regenerate their new tails in a few days. The new tail section is generally shorter than the original one and is composed of cartilage rather than vertebrae bone. In addition, the skin of the regenerated tail distinctly differs from its original appearance. We performed a proteomics analysis for extracts derived from regenerating lizard tail tissues after amputation and found that endoplasmin (ENPL) was the main factor among proteins up-regulated in expression during regeneration. Thus, we performed further experiments to determine whether ENPL could induce chondrogenesis of tonsil-derived mesenchymal stem cells (T-MSCs). In this study, we found that chondrogenic differentiation was associated with an increase of ENPL expression by ER stress. We also found that ENPL was involved in chondrogenic differentiation of T-MSCs by suppressing extracellular signal-regulated kinase (ERK) phosphorylation.
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spelling pubmed-91525762022-06-06 Endoplasmin regulates differentiation of tonsil-derived mesenchymal stem cells into chondrocytes through ERK signaling Kim, Hye Ryeong Choi, Hyeongrok Park, Soon Yong Song, Young-Chul Kim, Jae-Ho Shim, Sangin Jun, Woojin Kim, Kyung-Jin Han, Jin Chi, Seung-Wook Leem, Sun-Hee Chung, Jin Woong BMB Rep Article It is well-known that some species of lizard have an exceptional ability known as caudal autotomy (voluntary self-amputation of the tail) as an anti-predation mechanism. After amputation occurs, they can regenerate their new tails in a few days. The new tail section is generally shorter than the original one and is composed of cartilage rather than vertebrae bone. In addition, the skin of the regenerated tail distinctly differs from its original appearance. We performed a proteomics analysis for extracts derived from regenerating lizard tail tissues after amputation and found that endoplasmin (ENPL) was the main factor among proteins up-regulated in expression during regeneration. Thus, we performed further experiments to determine whether ENPL could induce chondrogenesis of tonsil-derived mesenchymal stem cells (T-MSCs). In this study, we found that chondrogenic differentiation was associated with an increase of ENPL expression by ER stress. We also found that ENPL was involved in chondrogenic differentiation of T-MSCs by suppressing extracellular signal-regulated kinase (ERK) phosphorylation. Korean Society for Biochemistry and Molecular Biology 2022-05-31 2022-05-31 /pmc/articles/PMC9152576/ /pubmed/35168699 http://dx.doi.org/10.5483/BMBRep.2022.55.5.173 Text en Copyright © 2022 by the The Korean Society for Biochemistry and Molecular Biology https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Article
Kim, Hye Ryeong
Choi, Hyeongrok
Park, Soon Yong
Song, Young-Chul
Kim, Jae-Ho
Shim, Sangin
Jun, Woojin
Kim, Kyung-Jin
Han, Jin
Chi, Seung-Wook
Leem, Sun-Hee
Chung, Jin Woong
Endoplasmin regulates differentiation of tonsil-derived mesenchymal stem cells into chondrocytes through ERK signaling
title Endoplasmin regulates differentiation of tonsil-derived mesenchymal stem cells into chondrocytes through ERK signaling
title_full Endoplasmin regulates differentiation of tonsil-derived mesenchymal stem cells into chondrocytes through ERK signaling
title_fullStr Endoplasmin regulates differentiation of tonsil-derived mesenchymal stem cells into chondrocytes through ERK signaling
title_full_unstemmed Endoplasmin regulates differentiation of tonsil-derived mesenchymal stem cells into chondrocytes through ERK signaling
title_short Endoplasmin regulates differentiation of tonsil-derived mesenchymal stem cells into chondrocytes through ERK signaling
title_sort endoplasmin regulates differentiation of tonsil-derived mesenchymal stem cells into chondrocytes through erk signaling
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9152576/
https://www.ncbi.nlm.nih.gov/pubmed/35168699
http://dx.doi.org/10.5483/BMBRep.2022.55.5.173
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