The epilepsy-associated protein PCDH19 undergoes NMDA receptor-dependent proteolytic cleavage and regulates the expression of immediate-early genes

Protocadherin-19 (PCDH19) is a synaptic cell-adhesion molecule encoded by X-linked PCDH19, a gene linked with epilepsy. Here, we report a synapse-to-nucleus signaling pathway through which PCDH19 bridges neuronal activity with gene expression. In particular, we describe the NMDA receptor (NMDAR)-dep...

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Detalles Bibliográficos
Autores principales: Gerosa, Laura, Mazzoleni, Sara, Rusconi, Francesco, Longaretti, Alessandra, Lewerissa, Elly, Pelucchi, Silvia, Murru, Luca, Giannelli, Serena Gea, Broccoli, Vania, Marcello, Elena, Kasri, Nael Nadif, Battaglioli, Elena, Passafaro, Maria, Bassani, Silvia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9152703/
https://www.ncbi.nlm.nih.gov/pubmed/35613587
http://dx.doi.org/10.1016/j.celrep.2022.110857

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