Rippling Muscle Disease with Irregular Toe Jerks and Anti-acetylcholine Receptor Antibodies: Remission after Extended Thymectomy

We herein report a 63-year-old rippling muscle disease (RMD) patient who presented with painless stiffness, muscle hypertrophy and muscle contractions elicited by mechanical stimulation. He also showed irregular toe jerks and a slightly elevated level of anti-acetylcholine receptor antibody (AChR-Ab...

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Autores principales: Yamaguchi, Nanaka, Matsuda, Shunichi, Matsumoto, Jun, Ugawa, Yoshikazu, Shimizu, Jun, Toda, Tatsushi, Sonoo, Masahiro, Yoshizawa, Toshihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9152870/
https://www.ncbi.nlm.nih.gov/pubmed/34670892
http://dx.doi.org/10.2169/internalmedicine.8146-21
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author Yamaguchi, Nanaka
Matsuda, Shunichi
Matsumoto, Jun
Ugawa, Yoshikazu
Shimizu, Jun
Toda, Tatsushi
Sonoo, Masahiro
Yoshizawa, Toshihiro
author_facet Yamaguchi, Nanaka
Matsuda, Shunichi
Matsumoto, Jun
Ugawa, Yoshikazu
Shimizu, Jun
Toda, Tatsushi
Sonoo, Masahiro
Yoshizawa, Toshihiro
author_sort Yamaguchi, Nanaka
collection PubMed
description We herein report a 63-year-old rippling muscle disease (RMD) patient who presented with painless stiffness, muscle hypertrophy and muscle contractions elicited by mechanical stimulation. He also showed irregular toe jerks and a slightly elevated level of anti-acetylcholine receptor antibody (AChR-Ab). Since he had a mediastinal mass mimicking thymoma, which was later revealed to be a bronchial cyst, he underwent extended thymectomy. The irregular toe jerks disappeared within a week after the operation. The other muscle symptoms completely remitted 27 months after the onset. This is the first report of a sporadic case of RMD with irregular toe jerks that resolved after extended thymectomy.
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spelling pubmed-91528702022-06-13 Rippling Muscle Disease with Irregular Toe Jerks and Anti-acetylcholine Receptor Antibodies: Remission after Extended Thymectomy Yamaguchi, Nanaka Matsuda, Shunichi Matsumoto, Jun Ugawa, Yoshikazu Shimizu, Jun Toda, Tatsushi Sonoo, Masahiro Yoshizawa, Toshihiro Intern Med Case Report We herein report a 63-year-old rippling muscle disease (RMD) patient who presented with painless stiffness, muscle hypertrophy and muscle contractions elicited by mechanical stimulation. He also showed irregular toe jerks and a slightly elevated level of anti-acetylcholine receptor antibody (AChR-Ab). Since he had a mediastinal mass mimicking thymoma, which was later revealed to be a bronchial cyst, he underwent extended thymectomy. The irregular toe jerks disappeared within a week after the operation. The other muscle symptoms completely remitted 27 months after the onset. This is the first report of a sporadic case of RMD with irregular toe jerks that resolved after extended thymectomy. The Japanese Society of Internal Medicine 2021-10-19 2022-05-01 /pmc/articles/PMC9152870/ /pubmed/34670892 http://dx.doi.org/10.2169/internalmedicine.8146-21 Text en Copyright © 2022 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Yamaguchi, Nanaka
Matsuda, Shunichi
Matsumoto, Jun
Ugawa, Yoshikazu
Shimizu, Jun
Toda, Tatsushi
Sonoo, Masahiro
Yoshizawa, Toshihiro
Rippling Muscle Disease with Irregular Toe Jerks and Anti-acetylcholine Receptor Antibodies: Remission after Extended Thymectomy
title Rippling Muscle Disease with Irregular Toe Jerks and Anti-acetylcholine Receptor Antibodies: Remission after Extended Thymectomy
title_full Rippling Muscle Disease with Irregular Toe Jerks and Anti-acetylcholine Receptor Antibodies: Remission after Extended Thymectomy
title_fullStr Rippling Muscle Disease with Irregular Toe Jerks and Anti-acetylcholine Receptor Antibodies: Remission after Extended Thymectomy
title_full_unstemmed Rippling Muscle Disease with Irregular Toe Jerks and Anti-acetylcholine Receptor Antibodies: Remission after Extended Thymectomy
title_short Rippling Muscle Disease with Irregular Toe Jerks and Anti-acetylcholine Receptor Antibodies: Remission after Extended Thymectomy
title_sort rippling muscle disease with irregular toe jerks and anti-acetylcholine receptor antibodies: remission after extended thymectomy
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9152870/
https://www.ncbi.nlm.nih.gov/pubmed/34670892
http://dx.doi.org/10.2169/internalmedicine.8146-21
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