Successful Treatment of Symptomatic Epilepsy with Oral Valproic Acid and Levetiracetam in a Patient with Short-bowel Syndrome

Valproic acid (VPA) and levetiracetam (LEV) are used in epilepsy treatment. However, their use to treat short-bowel syndrome has not been reported. We herein report a 68-year-old man who was hospitalized for symptomatic epilepsy following cerebral infarction. He had a history of superior mesenteric...

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Autores principales: Kurishima, Akira, Hayashi, Mototaka, Shimozato, Rin, Isozaki, Ryo, Shioda, Tomoko, Iijima, Akira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9152876/
https://www.ncbi.nlm.nih.gov/pubmed/34670882
http://dx.doi.org/10.2169/internalmedicine.7622-21
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author Kurishima, Akira
Hayashi, Mototaka
Shimozato, Rin
Isozaki, Ryo
Shioda, Tomoko
Iijima, Akira
author_facet Kurishima, Akira
Hayashi, Mototaka
Shimozato, Rin
Isozaki, Ryo
Shioda, Tomoko
Iijima, Akira
author_sort Kurishima, Akira
collection PubMed
description Valproic acid (VPA) and levetiracetam (LEV) are used in epilepsy treatment. However, their use to treat short-bowel syndrome has not been reported. We herein report a 68-year-old man who was hospitalized for symptomatic epilepsy following cerebral infarction. He had a history of superior mesenteric arterial occlusion, and only 30 cm of his jejunum was intact. VPA and LEV were administered, and good blood levels were achieved at clinical doses. This suggests that the gastrointestinal tract absorption of LEV and VPA is good even in patients with short-bowel syndrome and a 30-cm jejunum.
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spelling pubmed-91528762022-06-13 Successful Treatment of Symptomatic Epilepsy with Oral Valproic Acid and Levetiracetam in a Patient with Short-bowel Syndrome Kurishima, Akira Hayashi, Mototaka Shimozato, Rin Isozaki, Ryo Shioda, Tomoko Iijima, Akira Intern Med Case Report Valproic acid (VPA) and levetiracetam (LEV) are used in epilepsy treatment. However, their use to treat short-bowel syndrome has not been reported. We herein report a 68-year-old man who was hospitalized for symptomatic epilepsy following cerebral infarction. He had a history of superior mesenteric arterial occlusion, and only 30 cm of his jejunum was intact. VPA and LEV were administered, and good blood levels were achieved at clinical doses. This suggests that the gastrointestinal tract absorption of LEV and VPA is good even in patients with short-bowel syndrome and a 30-cm jejunum. The Japanese Society of Internal Medicine 2021-10-19 2022-05-01 /pmc/articles/PMC9152876/ /pubmed/34670882 http://dx.doi.org/10.2169/internalmedicine.7622-21 Text en Copyright © 2022 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Kurishima, Akira
Hayashi, Mototaka
Shimozato, Rin
Isozaki, Ryo
Shioda, Tomoko
Iijima, Akira
Successful Treatment of Symptomatic Epilepsy with Oral Valproic Acid and Levetiracetam in a Patient with Short-bowel Syndrome
title Successful Treatment of Symptomatic Epilepsy with Oral Valproic Acid and Levetiracetam in a Patient with Short-bowel Syndrome
title_full Successful Treatment of Symptomatic Epilepsy with Oral Valproic Acid and Levetiracetam in a Patient with Short-bowel Syndrome
title_fullStr Successful Treatment of Symptomatic Epilepsy with Oral Valproic Acid and Levetiracetam in a Patient with Short-bowel Syndrome
title_full_unstemmed Successful Treatment of Symptomatic Epilepsy with Oral Valproic Acid and Levetiracetam in a Patient with Short-bowel Syndrome
title_short Successful Treatment of Symptomatic Epilepsy with Oral Valproic Acid and Levetiracetam in a Patient with Short-bowel Syndrome
title_sort successful treatment of symptomatic epilepsy with oral valproic acid and levetiracetam in a patient with short-bowel syndrome
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9152876/
https://www.ncbi.nlm.nih.gov/pubmed/34670882
http://dx.doi.org/10.2169/internalmedicine.7622-21
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