Apoptosis reprogramming triggered by splicing inhibitors sensitizes multiple myeloma cells to Venetoclax treatment

Identification of novel vulnerabilities in the context of therapeutic resistance is emerging as a key challenge for cancer treatment. Recent studies have detected pervasive aberrant splicing in cancer cells, supporting its targeting for novel therapeutic strategies. Here, we evaluated the expression...

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Detalles Bibliográficos
Autores principales: Soncini, Debora, Martinuzzi, Claudia, Becherini, Pamela, Gelli, Elisa, Ruberti, Samantha, Todoerti, Katia, Mastracci, Luca, Contini, Paola, Cagnetta, Antonia, Laudisi, Antonella, Guolo, Fabio, Minetto, Paola, Miglino, Maurizio, Aquino, Sara, Varaldo, Riccardo, Reverberi, Daniele, Formica, Matteo, Passalacqua, Mario, Nencioni, Alessio, Neri, Antonino, Samur, Mehmet K., Munshi, Nikhil C., Fulciniti, Mariateresa, Lemoli, Roberto M., Cea., Michele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Fondazione Ferrata Storti 2021
Materias:
Article - Plasma Cell Disorders
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9152954/
https://www.ncbi.nlm.nih.gov/pubmed/34670358
http://dx.doi.org/10.3324/haematol.2021.279276

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