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Ionophore-mediated swelling of erythrocytes as a therapeutic mechanism in sickle cell disease

Sickle cell disease (SCD) is characterized by sickle hemoglobin (HbS) which polymerizes under deoxygenated conditions to form a stiff, sickled erythrocyte. The dehydration of sickle erythrocytes increases intracellular HbS concentration and the propensity of erythrocyte sickling. Prevention of this...

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Detalles Bibliográficos
Autores principales:	Geisness1, Athena C., Azul, Melissa, Williams, Dillon, Szafraniec, Hannah, De Souza, Daniel C., Higgins, John M., Wood, David K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Fondazione Ferrata Storti 2021
Materias:	Article - Red Cell Biology & its Disorders
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9152977/ https://www.ncbi.nlm.nih.gov/pubmed/34706495 http://dx.doi.org/10.3324/haematol.2021.278666

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