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Predicting mortality from intracranial hemorrhage in patients who undergo allogeneic hematopoietic stem cell transplantation

Intracranial hemorrhage (ICH) is a rare but fatal central nervous system complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT). However, factors that are predictive of early mortality in patients who develop ICH after undergoing allo-HSCT have not been systemically investiga...

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Autores principales: Ren, Xiying, Huang, Qiusha, Qu, Qingyuan, Cai, Xuan, Fu, Haixia, Mo, Xiaodong, Wang, Yu, Zheng, Yawei, Jiang, Erlie, Ye, Yishan, Luo, Yi, Chen, Shaozhen, Yang, Ting, Zhang, Yuanyuan, Han, Wei, Tang, Feifei, Mo, Wenjian, Wang, Shunqing, Li, Fei, Liu, Daihong, Zhang, Xiaoying, Zhang, Yicheng, Feng, Shuqing, Gao, Feng, Yuan, Hailong, Wang, Dao, Wan, Dingming, Chen, Huan, Chen, Yao, Wang, Jingzhi, Chen, Yuhong, Wang, Ying, Xu, Kailin, Lang, Tao, Wang, Xiaomin, Meng, Hongbin, Li, Limin, Wang, Zhiguo, Fan, Yanling, Chang, Yingjun, Xu, Lanping, Huang, Xiaojun, Zhang, Xiaohui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Hematology 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9153001/
https://www.ncbi.nlm.nih.gov/pubmed/34448835
http://dx.doi.org/10.1182/bloodadvances.2021004349
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author Ren, Xiying
Huang, Qiusha
Qu, Qingyuan
Cai, Xuan
Fu, Haixia
Mo, Xiaodong
Wang, Yu
Zheng, Yawei
Jiang, Erlie
Ye, Yishan
Luo, Yi
Chen, Shaozhen
Yang, Ting
Zhang, Yuanyuan
Han, Wei
Tang, Feifei
Mo, Wenjian
Wang, Shunqing
Li, Fei
Liu, Daihong
Zhang, Xiaoying
Zhang, Yicheng
Feng, Shuqing
Gao, Feng
Yuan, Hailong
Wang, Dao
Wan, Dingming
Chen, Huan
Chen, Yao
Wang, Jingzhi
Chen, Yuhong
Wang, Ying
Xu, Kailin
Lang, Tao
Wang, Xiaomin
Meng, Hongbin
Li, Limin
Wang, Zhiguo
Fan, Yanling
Chang, Yingjun
Xu, Lanping
Huang, Xiaojun
Zhang, Xiaohui
author_facet Ren, Xiying
Huang, Qiusha
Qu, Qingyuan
Cai, Xuan
Fu, Haixia
Mo, Xiaodong
Wang, Yu
Zheng, Yawei
Jiang, Erlie
Ye, Yishan
Luo, Yi
Chen, Shaozhen
Yang, Ting
Zhang, Yuanyuan
Han, Wei
Tang, Feifei
Mo, Wenjian
Wang, Shunqing
Li, Fei
Liu, Daihong
Zhang, Xiaoying
Zhang, Yicheng
Feng, Shuqing
Gao, Feng
Yuan, Hailong
Wang, Dao
Wan, Dingming
Chen, Huan
Chen, Yao
Wang, Jingzhi
Chen, Yuhong
Wang, Ying
Xu, Kailin
Lang, Tao
Wang, Xiaomin
Meng, Hongbin
Li, Limin
Wang, Zhiguo
Fan, Yanling
Chang, Yingjun
Xu, Lanping
Huang, Xiaojun
Zhang, Xiaohui
author_sort Ren, Xiying
collection PubMed
description Intracranial hemorrhage (ICH) is a rare but fatal central nervous system complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT). However, factors that are predictive of early mortality in patients who develop ICH after undergoing allo-HSCT have not been systemically investigated. From January 2008 to June 2020, a total of 70 allo-HSCT patients with an ICH diagnosis formed the derivation cohort. Forty-one allo-HSCT patients with an ICH diagnosis were collected from 12 other medical centers during the same period, and they comprised the external validation cohort. These 2 cohorts were used to develop and validate a grading scale that enables the prediction of 30-day mortality from ICH in all-HSCT patients. Four predictors (lactate dehydrogenase level, albumin level, white blood cell count, and disease status) were retained in the multivariable logistic regression model, and a simplified grading scale (termed the LAWS score) was developed. The LAWS score was adequately calibrated (Hosmer-Lemeshow test, P > .05) in both cohorts. It had good discrimination power in both the derivation cohort (C-statistic, 0.859; 95% confidence interval, 0.776-0.945) and the external validation cohort (C-statistic, 0.795; 95% confidence interval, 0.645-0.945). The LAWS score is the first scoring system capable of predicting 30-day mortality from ICH in allo-HSCT patients. It showed good performance in identifying allo-HSCT patients at increased risk of early mortality after ICH diagnosis. We anticipate that it would help risk stratify allo-HSCT patients with ICH and facilitate future studies on developing individualized and novel interventions for patients within different LAWS risk groups.
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spelling pubmed-91530012022-05-31 Predicting mortality from intracranial hemorrhage in patients who undergo allogeneic hematopoietic stem cell transplantation Ren, Xiying Huang, Qiusha Qu, Qingyuan Cai, Xuan Fu, Haixia Mo, Xiaodong Wang, Yu Zheng, Yawei Jiang, Erlie Ye, Yishan Luo, Yi Chen, Shaozhen Yang, Ting Zhang, Yuanyuan Han, Wei Tang, Feifei Mo, Wenjian Wang, Shunqing Li, Fei Liu, Daihong Zhang, Xiaoying Zhang, Yicheng Feng, Shuqing Gao, Feng Yuan, Hailong Wang, Dao Wan, Dingming Chen, Huan Chen, Yao Wang, Jingzhi Chen, Yuhong Wang, Ying Xu, Kailin Lang, Tao Wang, Xiaomin Meng, Hongbin Li, Limin Wang, Zhiguo Fan, Yanling Chang, Yingjun Xu, Lanping Huang, Xiaojun Zhang, Xiaohui Blood Adv Transplantation Intracranial hemorrhage (ICH) is a rare but fatal central nervous system complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT). However, factors that are predictive of early mortality in patients who develop ICH after undergoing allo-HSCT have not been systemically investigated. From January 2008 to June 2020, a total of 70 allo-HSCT patients with an ICH diagnosis formed the derivation cohort. Forty-one allo-HSCT patients with an ICH diagnosis were collected from 12 other medical centers during the same period, and they comprised the external validation cohort. These 2 cohorts were used to develop and validate a grading scale that enables the prediction of 30-day mortality from ICH in all-HSCT patients. Four predictors (lactate dehydrogenase level, albumin level, white blood cell count, and disease status) were retained in the multivariable logistic regression model, and a simplified grading scale (termed the LAWS score) was developed. The LAWS score was adequately calibrated (Hosmer-Lemeshow test, P > .05) in both cohorts. It had good discrimination power in both the derivation cohort (C-statistic, 0.859; 95% confidence interval, 0.776-0.945) and the external validation cohort (C-statistic, 0.795; 95% confidence interval, 0.645-0.945). The LAWS score is the first scoring system capable of predicting 30-day mortality from ICH in allo-HSCT patients. It showed good performance in identifying allo-HSCT patients at increased risk of early mortality after ICH diagnosis. We anticipate that it would help risk stratify allo-HSCT patients with ICH and facilitate future studies on developing individualized and novel interventions for patients within different LAWS risk groups. American Society of Hematology 2021-11-30 /pmc/articles/PMC9153001/ /pubmed/34448835 http://dx.doi.org/10.1182/bloodadvances.2021004349 Text en © 2021 by The American Society of Hematology. Licensed under Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0), permitting only noncommercial, nonderivative use with attribution. All other rights reserved.
spellingShingle Transplantation
Ren, Xiying
Huang, Qiusha
Qu, Qingyuan
Cai, Xuan
Fu, Haixia
Mo, Xiaodong
Wang, Yu
Zheng, Yawei
Jiang, Erlie
Ye, Yishan
Luo, Yi
Chen, Shaozhen
Yang, Ting
Zhang, Yuanyuan
Han, Wei
Tang, Feifei
Mo, Wenjian
Wang, Shunqing
Li, Fei
Liu, Daihong
Zhang, Xiaoying
Zhang, Yicheng
Feng, Shuqing
Gao, Feng
Yuan, Hailong
Wang, Dao
Wan, Dingming
Chen, Huan
Chen, Yao
Wang, Jingzhi
Chen, Yuhong
Wang, Ying
Xu, Kailin
Lang, Tao
Wang, Xiaomin
Meng, Hongbin
Li, Limin
Wang, Zhiguo
Fan, Yanling
Chang, Yingjun
Xu, Lanping
Huang, Xiaojun
Zhang, Xiaohui
Predicting mortality from intracranial hemorrhage in patients who undergo allogeneic hematopoietic stem cell transplantation
title Predicting mortality from intracranial hemorrhage in patients who undergo allogeneic hematopoietic stem cell transplantation
title_full Predicting mortality from intracranial hemorrhage in patients who undergo allogeneic hematopoietic stem cell transplantation
title_fullStr Predicting mortality from intracranial hemorrhage in patients who undergo allogeneic hematopoietic stem cell transplantation
title_full_unstemmed Predicting mortality from intracranial hemorrhage in patients who undergo allogeneic hematopoietic stem cell transplantation
title_short Predicting mortality from intracranial hemorrhage in patients who undergo allogeneic hematopoietic stem cell transplantation
title_sort predicting mortality from intracranial hemorrhage in patients who undergo allogeneic hematopoietic stem cell transplantation
topic Transplantation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9153001/
https://www.ncbi.nlm.nih.gov/pubmed/34448835
http://dx.doi.org/10.1182/bloodadvances.2021004349
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