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GDP/GTP exchange factor MADD drives activation and recruitment of secretory Rab GTPases to Weibel-Palade bodies

von Willebrand factor (VWF) is an essential hemostatic protein that is synthesized and secreted by endothelial cells and stored in Weibel-Palade bodies (WPBs). The secretory Rab GTPases Rab27A, Rab3B, and Rab3D have been linked with WPB trafficking and secretion. How these Rabs are activated and rec...

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Detalles Bibliográficos
Autores principales:	Kat, Marije, Bürgisser, Petra E., Janssen, Hans, De Cuyper, Iris M., Conte, Ianina L., Hume, Alistair N., Carter, Tom, Voorberg, Jan, Margadant, Coert, Bierings, Ruben
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Hematology 2021
Materias:	Vascular Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9153003/ https://www.ncbi.nlm.nih.gov/pubmed/34551092 http://dx.doi.org/10.1182/bloodadvances.2021004827

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