ALL blasts drive primary mesenchymal stromal cells to increase asparagine availability during asparaginase treatment

Mechanisms underlying the resistance of acute lymphoblastic leukemia (ALL) blasts to l-asparaginase are still incompletely known. Here we demonstrate that human primary bone marrow mesenchymal stromal cells (MSCs) successfully adapt to l-asparaginase and markedly protect leukemic blasts from the enz...

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Detalles Bibliográficos
Autores principales: Chiu, Martina, Taurino, Giuseppe, Dander, Erica, Bardelli, Donatella, Fallati, Alessandra, Andreoli, Roberta, Bianchi, Massimiliano G., Carubbi, Cecilia, Pozzi, Giulia, Galuppo, Laura, Mirandola, Prisco, Rizzari, Carmelo, Tardito, Saverio, Biondi, Andrea, D’Amico, Giovanna, Bussolati, Ovidio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Hematology 2021
Materias:
Lymphoid Neoplasia
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9153005/
https://www.ncbi.nlm.nih.gov/pubmed/34614505
http://dx.doi.org/10.1182/bloodadvances.2020004041

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