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CBFB-MYH11 fusion transcripts distinguish acute myeloid leukemias with distinct molecular landscapes and outcomes

CBFB-MYH11 transcripts and KIT mutations predict relapse in AML. High-risk CBFB-MYH11 transcripts are associated with distinct transcriptional landscapes and upregulation of early hematopoiesis genes.

Detalles Bibliográficos
Autores principales: Huang, Benjamin J., Smith, Jenny L., Wang, Yi-Cheng, Taghizadeh, Kassra, Leonti, Amanda R., Ries, Rhonda E., Liu, Yanling, Kolekar, Pandurang, Tarlock, Katherine, Gerbing, Robert, Crowgey, Erin, Furlan, Scott N., Shaw, Timothy I., Hagiwara, Kohei, Wei, Lisa, Cooper, Todd M., Gamis, Alan S., Aplenc, Richard, Kolb, E. Anders, Farrar, Jason E., Triche, Timothy, Alonzo, Todd A., Ma, Xiaotu, Meshinchi, Soheil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Hematology 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9153007/
https://www.ncbi.nlm.nih.gov/pubmed/34547772
http://dx.doi.org/10.1182/bloodadvances.2021004965
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author Huang, Benjamin J.
Smith, Jenny L.
Wang, Yi-Cheng
Taghizadeh, Kassra
Leonti, Amanda R.
Ries, Rhonda E.
Liu, Yanling
Kolekar, Pandurang
Tarlock, Katherine
Gerbing, Robert
Crowgey, Erin
Furlan, Scott N.
Shaw, Timothy I.
Hagiwara, Kohei
Wei, Lisa
Cooper, Todd M.
Gamis, Alan S.
Aplenc, Richard
Kolb, E. Anders
Farrar, Jason E.
Triche, Timothy
Alonzo, Todd A.
Ma, Xiaotu
Meshinchi, Soheil
author_facet Huang, Benjamin J.
Smith, Jenny L.
Wang, Yi-Cheng
Taghizadeh, Kassra
Leonti, Amanda R.
Ries, Rhonda E.
Liu, Yanling
Kolekar, Pandurang
Tarlock, Katherine
Gerbing, Robert
Crowgey, Erin
Furlan, Scott N.
Shaw, Timothy I.
Hagiwara, Kohei
Wei, Lisa
Cooper, Todd M.
Gamis, Alan S.
Aplenc, Richard
Kolb, E. Anders
Farrar, Jason E.
Triche, Timothy
Alonzo, Todd A.
Ma, Xiaotu
Meshinchi, Soheil
author_sort Huang, Benjamin J.
collection PubMed
description CBFB-MYH11 transcripts and KIT mutations predict relapse in AML. High-risk CBFB-MYH11 transcripts are associated with distinct transcriptional landscapes and upregulation of early hematopoiesis genes.
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spelling pubmed-91530072022-05-31 CBFB-MYH11 fusion transcripts distinguish acute myeloid leukemias with distinct molecular landscapes and outcomes Huang, Benjamin J. Smith, Jenny L. Wang, Yi-Cheng Taghizadeh, Kassra Leonti, Amanda R. Ries, Rhonda E. Liu, Yanling Kolekar, Pandurang Tarlock, Katherine Gerbing, Robert Crowgey, Erin Furlan, Scott N. Shaw, Timothy I. Hagiwara, Kohei Wei, Lisa Cooper, Todd M. Gamis, Alan S. Aplenc, Richard Kolb, E. Anders Farrar, Jason E. Triche, Timothy Alonzo, Todd A. Ma, Xiaotu Meshinchi, Soheil Blood Adv Stimulus Report CBFB-MYH11 transcripts and KIT mutations predict relapse in AML. High-risk CBFB-MYH11 transcripts are associated with distinct transcriptional landscapes and upregulation of early hematopoiesis genes. American Society of Hematology 2021-11-30 /pmc/articles/PMC9153007/ /pubmed/34547772 http://dx.doi.org/10.1182/bloodadvances.2021004965 Text en © 2021 by The American Society of Hematology. Licensed under Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0), permitting only noncommercial, nonderivative use with attribution. All other rights reserved.
spellingShingle Stimulus Report
Huang, Benjamin J.
Smith, Jenny L.
Wang, Yi-Cheng
Taghizadeh, Kassra
Leonti, Amanda R.
Ries, Rhonda E.
Liu, Yanling
Kolekar, Pandurang
Tarlock, Katherine
Gerbing, Robert
Crowgey, Erin
Furlan, Scott N.
Shaw, Timothy I.
Hagiwara, Kohei
Wei, Lisa
Cooper, Todd M.
Gamis, Alan S.
Aplenc, Richard
Kolb, E. Anders
Farrar, Jason E.
Triche, Timothy
Alonzo, Todd A.
Ma, Xiaotu
Meshinchi, Soheil
CBFB-MYH11 fusion transcripts distinguish acute myeloid leukemias with distinct molecular landscapes and outcomes
title CBFB-MYH11 fusion transcripts distinguish acute myeloid leukemias with distinct molecular landscapes and outcomes
title_full CBFB-MYH11 fusion transcripts distinguish acute myeloid leukemias with distinct molecular landscapes and outcomes
title_fullStr CBFB-MYH11 fusion transcripts distinguish acute myeloid leukemias with distinct molecular landscapes and outcomes
title_full_unstemmed CBFB-MYH11 fusion transcripts distinguish acute myeloid leukemias with distinct molecular landscapes and outcomes
title_short CBFB-MYH11 fusion transcripts distinguish acute myeloid leukemias with distinct molecular landscapes and outcomes
title_sort cbfb-myh11 fusion transcripts distinguish acute myeloid leukemias with distinct molecular landscapes and outcomes
topic Stimulus Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9153007/
https://www.ncbi.nlm.nih.gov/pubmed/34547772
http://dx.doi.org/10.1182/bloodadvances.2021004965
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