NUDT15 variants confer high incidence of second malignancies in children with acute lymphoblastic leukemia

The effect of genetic variation on second malignant neoplasms (SMNs) remains unclear. First, we identified the pathogenic germline variants in cancer-predisposing genes among 15 children with SMNs after childhood leukemia/lymphoma using whole-exome sequencing. Because the prevalence was low, we focu...

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Detalles Bibliográficos
Autores principales: Yoshida, Masanori, Nakabayashi, Kazuhiko, Yang, Wentao, Sato-Otsubo, Aiko, Tsujimoto, Shin-ichi, Ogata-Kawata, Hiroko, Kawai, Tomoko, Ishiwata, Keisuke, Sakamoto, Mika, Okamura, Kohji, Yoshida, Kaoru, Shirai, Ryota, Osumi, Tomoo, Moriyama, Takaya, Nishii, Rina, Takahashi, Hiroyuki, Kiyotani, Chikako, Shioda, Yoko, Terashima, Keita, Ishimaru, Sae, Yuza, Yuki, Takagi, Masatoshi, Arakawa, Yuki, Kinoshita, Akitoshi, Hino, Moeko, Imamura, Toshihiko, Hasegawa, Daisuke, Nakazawa, Yozo, Okuya, Mayuko, Kakuda, Harumi, Takasugi, Nao, Inoue, Akiko, Ohki, Kentaro, Yoshioka, Takako, Ito, Shuichi, Tomizawa, Daisuke, Koh, Katsuyoshi, Matsumoto, Kimikazu, Sanada, Masashi, Kiyokawa, Nobutaka, Ohara, Akira, Ogawa, Seishi, Manabe, Atsushi, Niwa, Akira, Hata, Kenichiro, Yang, Jun J., Kato, Motohiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Hematology 2021
Materias:
Lymphoid Neoplasia
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9153020/
https://www.ncbi.nlm.nih.gov/pubmed/34662904
http://dx.doi.org/10.1182/bloodadvances.2021005507

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