Defining the transcriptional control of pediatric AML highlights RARA as a superenhancer-regulated druggable dependency

Somatic mutations are rare in pediatric acute myeloid leukemia (pAML), indicating that alternate strategies are needed to identify targetable dependencies. We performed the first enhancer mapping of pAML in 22 patient samples. Generally, pAML samples were distinct from adult AML samples, and MLL (KM...

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Detalles Bibliográficos
Autores principales: Perez, Monika W., Sias-Garcia, Oscar, Daramola, Alfred, Wei, Helen, Terrell, Maci, Rashid, Raushan, Park, Woojun D., Duong, Kevin, Horton, Terzah M., Li, Feng, Cherayil, Nikitha, Koren, Jost Vrabic, Gant, Vincent U., Junco, Jacob J., Curry, Choladda V., Stevens, Alexandra M., Lin, Charles Y., Yi, Joanna S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Hematology 2021
Materias:
Myeloid Neoplasia
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9153032/
https://www.ncbi.nlm.nih.gov/pubmed/34543389
http://dx.doi.org/10.1182/bloodadvances.2020003737

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