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The immunometabolite itaconate inhibits heme synthesis and remodels cellular metabolism in erythroid precursors
As part of the inflammatory response by macrophages, Irg1 is induced, resulting in millimolar quantities of itaconate being produced. This immunometabolite remodels the macrophage metabolome and acts as an antimicrobial agent when excreted. Itaconate is not synthesized within the erythron but instea...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society of Hematology
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9153040/ https://www.ncbi.nlm.nih.gov/pubmed/34492704 http://dx.doi.org/10.1182/bloodadvances.2021004750 |