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Cleavage of talin by calpain promotes platelet-mediated fibrin clot contraction

Blood clot contraction is driven by traction forces generated by the platelet cytoskeleton that are transmitted to fibrin fibers via the integrin αIIbβ3. Here we show that clot contraction is impaired by inhibitors of the platelet cytosolic protease calpain. We used subtiligase-mediated labeling of...

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Detalles Bibliográficos
Autores principales:	Fong, Karen P., Molnar, Kathleen S., Agard, Nicholas, Litvinov, Rustem I., Kim, Oleg V., Wells, James A., Weisel, John W., DeGrado, William F., Bennett, Joel S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Hematology 2021
Materias:	Thrombosis and Hemostasis
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9153048/ https://www.ncbi.nlm.nih.gov/pubmed/34570183 http://dx.doi.org/10.1182/bloodadvances.2021004582

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