Cargando…
Differential sialic acid content in adult and neonatal fibrinogen mediates differences in clot polymerization dynamics
Neonates possess a molecular variant of fibrinogen, known as fetal fibrinogen, characterized by increased sialic acid, a greater negative charge, and decreased activity compared with adults. Despite these differences, adult fibrinogen is used for the treatment of bleeding in neonates, with mixed eff...
| Autores principales: | , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society of Hematology
2021
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9153052/ https://www.ncbi.nlm.nih.gov/pubmed/34555851 http://dx.doi.org/10.1182/bloodadvances.2021004417 |