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The H3K27M mutation alters stem cell growth, epigenetic regulation, and differentiation potential
BACKGROUND: Neurodevelopmental disorders increase brain tumor risk, suggesting that normal brain development may have protective properties. Mutations in epigenetic regulators are common in pediatric brain tumors, highlighting a potentially central role for disrupted epigenetic regulation of normal...
Autores principales: | Kfoury-Beaumont, N., Prakasam, R., Pondugula, S., Lagas, J. S., Matkovich, S., Gontarz, P., Yang, L., Yano, H., Kim, A. H., Rubin, J. B., Kroll, K. L. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9153095/ https://www.ncbi.nlm.nih.gov/pubmed/35637482 http://dx.doi.org/10.1186/s12915-022-01324-0 |
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