mTOR pathway gene mutations predict response to immune checkpoint inhibitors in multiple cancers

BACKGROUND: mTOR pathway is known to promote cancer malignancy and influence cancer immunity but is unknown for its role in immune checkpoint inhibitors (ICI) therapy. METHODS: Using Memorial Sloan-Kettering Cancer Center dataset (MSKCC), we extracted mTOR pathway gene mutations for stepwise Cox reg...

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Detalles Bibliográficos
Autores principales: Cheng, Lei, Wang, Yanan, Qiu, Lixin, Chang, Yuanyuan, Lu, Haijiao, Liu, Chenchen, Zhang, Bo, Zhou, Yan, Bai, Hao, Xiong, Liwen, Zhong, Hua, Nie, Wei, Han, Baohui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9153162/
https://www.ncbi.nlm.nih.gov/pubmed/35642038
http://dx.doi.org/10.1186/s12967-022-03436-1

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