Evaluation of Rapid Antigen Detection Kits for Detection of SARS-CoV-2 B.1.1.529

BACKGROUND: Currently, there is a lack of studies evaluating rapid antigen detection (RAD) kits to detect SARS-CoV-2 B.1.1.529. OBJECTIVE: To evaluate the analytical sensitivity of seven RAD kits to detect SARS-CoV-2 B.1.1.529. STUDY DESIGN: The analytical sensitivity was determined by means of limi...

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Autores principales: Mak, Gannon C. K., Lau, Stephen S. Y., Wong, Kitty K. Y., Lau, C. S., Lam, Edman T. K., Ng, Ken H. L., Chan, Rickjason C. W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2022
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9153237/
http://dx.doi.org/10.1007/s44229-022-00009-8
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author Mak, Gannon C. K.
Lau, Stephen S. Y.
Wong, Kitty K. Y.
Lau, C. S.
Lam, Edman T. K.
Ng, Ken H. L.
Chan, Rickjason C. W.
author_facet Mak, Gannon C. K.
Lau, Stephen S. Y.
Wong, Kitty K. Y.
Lau, C. S.
Lam, Edman T. K.
Ng, Ken H. L.
Chan, Rickjason C. W.
author_sort Mak, Gannon C. K.
collection PubMed
description BACKGROUND: Currently, there is a lack of studies evaluating rapid antigen detection (RAD) kits to detect SARS-CoV-2 B.1.1.529. OBJECTIVE: To evaluate the analytical sensitivity of seven RAD kits to detect SARS-CoV-2 B.1.1.529. STUDY DESIGN: The analytical sensitivity was determined by means of limit of detection (LOD). A dilution set using a respiratory specimen collected from a COVID-19 patient infected with SARS-CoV-2 B.1.1.529 was prepared. RT-PCR was used as a reference method. RESULTS: The LOD results showed that all seven RAD kits had comparable analytical sensitivity for detection of SARS-CoV-2 B.1.1.529. CONCLUSIONS: The RAD kits selected in the current study may be used for first-line screening of the recently emerged SARS-CoV-2 B.1.1.529.
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spelling pubmed-91532372022-06-02 Evaluation of Rapid Antigen Detection Kits for Detection of SARS-CoV-2 B.1.1.529 Mak, Gannon C. K. Lau, Stephen S. Y. Wong, Kitty K. Y. Lau, C. S. Lam, Edman T. K. Ng, Ken H. L. Chan, Rickjason C. W. Dr. Sulaiman Al Habib Med J Short Communication BACKGROUND: Currently, there is a lack of studies evaluating rapid antigen detection (RAD) kits to detect SARS-CoV-2 B.1.1.529. OBJECTIVE: To evaluate the analytical sensitivity of seven RAD kits to detect SARS-CoV-2 B.1.1.529. STUDY DESIGN: The analytical sensitivity was determined by means of limit of detection (LOD). A dilution set using a respiratory specimen collected from a COVID-19 patient infected with SARS-CoV-2 B.1.1.529 was prepared. RT-PCR was used as a reference method. RESULTS: The LOD results showed that all seven RAD kits had comparable analytical sensitivity for detection of SARS-CoV-2 B.1.1.529. CONCLUSIONS: The RAD kits selected in the current study may be used for first-line screening of the recently emerged SARS-CoV-2 B.1.1.529. Springer Netherlands 2022-05-31 2022 /pmc/articles/PMC9153237/ http://dx.doi.org/10.1007/s44229-022-00009-8 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Short Communication
Mak, Gannon C. K.
Lau, Stephen S. Y.
Wong, Kitty K. Y.
Lau, C. S.
Lam, Edman T. K.
Ng, Ken H. L.
Chan, Rickjason C. W.
Evaluation of Rapid Antigen Detection Kits for Detection of SARS-CoV-2 B.1.1.529
title Evaluation of Rapid Antigen Detection Kits for Detection of SARS-CoV-2 B.1.1.529
title_full Evaluation of Rapid Antigen Detection Kits for Detection of SARS-CoV-2 B.1.1.529
title_fullStr Evaluation of Rapid Antigen Detection Kits for Detection of SARS-CoV-2 B.1.1.529
title_full_unstemmed Evaluation of Rapid Antigen Detection Kits for Detection of SARS-CoV-2 B.1.1.529
title_short Evaluation of Rapid Antigen Detection Kits for Detection of SARS-CoV-2 B.1.1.529
title_sort evaluation of rapid antigen detection kits for detection of sars-cov-2 b.1.1.529
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9153237/
http://dx.doi.org/10.1007/s44229-022-00009-8
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