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Molecular innovations in plant TIR-based immunity signaling

A protein domain (Toll and Interleukin-1 receptor [TIR]-like) with homology to animal TIRs mediates immune signaling in prokaryotes and eukaryotes. Here, we present an overview of TIR evolution and the molecular versatility of TIR domains in different protein architectures for host protection agains...

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Detalles Bibliográficos
Autores principales: Lapin, Dmitry, Johanndrees, Oliver, Wu, Zhongshou, Li, Xin, Parker, Jane E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9153377/
https://www.ncbi.nlm.nih.gov/pubmed/35143666
http://dx.doi.org/10.1093/plcell/koac035
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author Lapin, Dmitry
Johanndrees, Oliver
Wu, Zhongshou
Li, Xin
Parker, Jane E
author_facet Lapin, Dmitry
Johanndrees, Oliver
Wu, Zhongshou
Li, Xin
Parker, Jane E
author_sort Lapin, Dmitry
collection PubMed
description A protein domain (Toll and Interleukin-1 receptor [TIR]-like) with homology to animal TIRs mediates immune signaling in prokaryotes and eukaryotes. Here, we present an overview of TIR evolution and the molecular versatility of TIR domains in different protein architectures for host protection against microbial attack. Plant TIR-based signaling emerges as being central to the potentiation and effectiveness of host defenses triggered by intracellular and cell-surface immune receptors. Equally relevant for plant fitness are mechanisms that limit potent TIR signaling in healthy tissues but maintain preparedness for infection. We propose that seed plants evolved a specialized protein module to selectively translate TIR enzymatic activities to defense outputs, overlaying a more general function of TIRs.
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spelling pubmed-91533772022-06-04 Molecular innovations in plant TIR-based immunity signaling Lapin, Dmitry Johanndrees, Oliver Wu, Zhongshou Li, Xin Parker, Jane E Plant Cell Focus on Plant Biotic Interactions A protein domain (Toll and Interleukin-1 receptor [TIR]-like) with homology to animal TIRs mediates immune signaling in prokaryotes and eukaryotes. Here, we present an overview of TIR evolution and the molecular versatility of TIR domains in different protein architectures for host protection against microbial attack. Plant TIR-based signaling emerges as being central to the potentiation and effectiveness of host defenses triggered by intracellular and cell-surface immune receptors. Equally relevant for plant fitness are mechanisms that limit potent TIR signaling in healthy tissues but maintain preparedness for infection. We propose that seed plants evolved a specialized protein module to selectively translate TIR enzymatic activities to defense outputs, overlaying a more general function of TIRs. Oxford University Press 2022-02-10 /pmc/articles/PMC9153377/ /pubmed/35143666 http://dx.doi.org/10.1093/plcell/koac035 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of American Society of Plant Biologists. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Focus on Plant Biotic Interactions
Lapin, Dmitry
Johanndrees, Oliver
Wu, Zhongshou
Li, Xin
Parker, Jane E
Molecular innovations in plant TIR-based immunity signaling
title Molecular innovations in plant TIR-based immunity signaling
title_full Molecular innovations in plant TIR-based immunity signaling
title_fullStr Molecular innovations in plant TIR-based immunity signaling
title_full_unstemmed Molecular innovations in plant TIR-based immunity signaling
title_short Molecular innovations in plant TIR-based immunity signaling
title_sort molecular innovations in plant tir-based immunity signaling
topic Focus on Plant Biotic Interactions
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9153377/
https://www.ncbi.nlm.nih.gov/pubmed/35143666
http://dx.doi.org/10.1093/plcell/koac035
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