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Deficits in Acoustic Startle Reactivity and Auditory Temporal Processing after Traumatic Brain Injury

Traumatic brain injury (TBI) exacts significant neurological and financial costs on patients and their families. In adult patients with moderate-to-severe TBI, central auditory impairments have been reported. These auditory impairments may interfere with language receptivity, as observed in children...

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Autores principales: Threlkeld, Steven W., Cestero, Emma Morales, Marshall, John, Szmydynger-Chodobska, Joanna, Chodobski, Adam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mary Ann Liebert, Inc., publishers 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9153990/
https://www.ncbi.nlm.nih.gov/pubmed/35734394
http://dx.doi.org/10.1089/neur.2021.0077
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author Threlkeld, Steven W.
Cestero, Emma Morales
Marshall, John
Szmydynger-Chodobska, Joanna
Chodobski, Adam
author_facet Threlkeld, Steven W.
Cestero, Emma Morales
Marshall, John
Szmydynger-Chodobska, Joanna
Chodobski, Adam
author_sort Threlkeld, Steven W.
collection PubMed
description Traumatic brain injury (TBI) exacts significant neurological and financial costs on patients and their families. In adult patients with moderate-to-severe TBI, central auditory impairments have been reported. These auditory impairments may interfere with language receptivity, as observed in children with developmental brain injury. Although rodent models of TBI have been widely used to examine behavioral outcomes, few studies have evaluated how TBI affects higher-order central auditory processing across a range of cue complexities. Here, auditory processing was assessed using a modified acoustic startle paradigm. We used a battery of progressively complex stimuli (single-tone, silent gaps in white noise, and frequency-modulated [FM] sweeps) in adult rats that received unilateral controlled cortical impact injury. TBI subjects showed significant reductions in acoustic startle absolute responses across nearly all stimuli, regardless of cue, duration of stimuli, or cue complexity. Despite this overall reduction of startle magnitudes in injured animals, the detection of single-tone stimuli was comparable between TBI and sham-injured subjects, indicating intact hearing after TBI. TBI subjects showed deficits in rapid gap (5 ms) and FM sweep (175 ms) detection, and, in contrast to shams, they did not improve on detecting silent gaps and FM sweeps across days of testing. Our findings provide evidence for both low-level (brainstem-mediated) and higher-order central auditory processing deficits in a rodent model of TBI, which parallel sensory impairments observed in TBI patients. The present findings support the use of modified pre-pule auditory detection paradigms to investigate clinically relevant processes in TBI.
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spelling pubmed-91539902022-06-21 Deficits in Acoustic Startle Reactivity and Auditory Temporal Processing after Traumatic Brain Injury Threlkeld, Steven W. Cestero, Emma Morales Marshall, John Szmydynger-Chodobska, Joanna Chodobski, Adam Neurotrauma Rep Original Article Traumatic brain injury (TBI) exacts significant neurological and financial costs on patients and their families. In adult patients with moderate-to-severe TBI, central auditory impairments have been reported. These auditory impairments may interfere with language receptivity, as observed in children with developmental brain injury. Although rodent models of TBI have been widely used to examine behavioral outcomes, few studies have evaluated how TBI affects higher-order central auditory processing across a range of cue complexities. Here, auditory processing was assessed using a modified acoustic startle paradigm. We used a battery of progressively complex stimuli (single-tone, silent gaps in white noise, and frequency-modulated [FM] sweeps) in adult rats that received unilateral controlled cortical impact injury. TBI subjects showed significant reductions in acoustic startle absolute responses across nearly all stimuli, regardless of cue, duration of stimuli, or cue complexity. Despite this overall reduction of startle magnitudes in injured animals, the detection of single-tone stimuli was comparable between TBI and sham-injured subjects, indicating intact hearing after TBI. TBI subjects showed deficits in rapid gap (5 ms) and FM sweep (175 ms) detection, and, in contrast to shams, they did not improve on detecting silent gaps and FM sweeps across days of testing. Our findings provide evidence for both low-level (brainstem-mediated) and higher-order central auditory processing deficits in a rodent model of TBI, which parallel sensory impairments observed in TBI patients. The present findings support the use of modified pre-pule auditory detection paradigms to investigate clinically relevant processes in TBI. Mary Ann Liebert, Inc., publishers 2022-05-06 /pmc/articles/PMC9153990/ /pubmed/35734394 http://dx.doi.org/10.1089/neur.2021.0077 Text en © Steven W. Threlkeld et al., 2022; Published by Mary Ann Liebert, Inc. https://creativecommons.org/licenses/by/4.0/This Open Access article is distributed under the terms of the Creative Commons License [CC-BY] (http://creativecommons.org/licenses/by/4.0 (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Threlkeld, Steven W.
Cestero, Emma Morales
Marshall, John
Szmydynger-Chodobska, Joanna
Chodobski, Adam
Deficits in Acoustic Startle Reactivity and Auditory Temporal Processing after Traumatic Brain Injury
title Deficits in Acoustic Startle Reactivity and Auditory Temporal Processing after Traumatic Brain Injury
title_full Deficits in Acoustic Startle Reactivity and Auditory Temporal Processing after Traumatic Brain Injury
title_fullStr Deficits in Acoustic Startle Reactivity and Auditory Temporal Processing after Traumatic Brain Injury
title_full_unstemmed Deficits in Acoustic Startle Reactivity and Auditory Temporal Processing after Traumatic Brain Injury
title_short Deficits in Acoustic Startle Reactivity and Auditory Temporal Processing after Traumatic Brain Injury
title_sort deficits in acoustic startle reactivity and auditory temporal processing after traumatic brain injury
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9153990/
https://www.ncbi.nlm.nih.gov/pubmed/35734394
http://dx.doi.org/10.1089/neur.2021.0077
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