The dilemma of cytomegalovirus and hepatitis B virus interaction

Hepatitis B virus (HBV) remains a global public health problem despite the availability of effective vaccine and antiviral therapy. Cytomegalovirus (CMV), another hepatotropic virus, is also very prevalent in the general population worldwide. Both HBV and CMV can persist in the host and have potenti...

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Detalles Bibliográficos
Autores principales: Khan, Muzammil M, Ali, Mukarram J, Hanif, Hira, Maqsood, Muhammad H, Ahmad, Imama, Alvarez, Javier E G, Catana, Maria-Andreea, Lau, Daryl T Y
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9154071/
https://www.ncbi.nlm.nih.gov/pubmed/35663152
http://dx.doi.org/10.1093/gastro/goac018
Descripción
Sumario:Hepatitis B virus (HBV) remains a global public health problem despite the availability of effective vaccine and antiviral therapy. Cytomegalovirus (CMV), another hepatotropic virus, is also very prevalent in the general population worldwide. Both HBV and CMV can persist in the host and have potential to reactivate especially with weakened host cellular immunity. Superimposed CMV infection can lead to severe HBV reactivation. The pathogenesis of the co-infection of HBV and CMV remains poorly understood. Studies reported conflicting results regarding the inhibitory effect of CMV on HBV replication. There is an unmet need on the management of co-infection of HBV and CMV; research initiatives dedicated to understanding their interactions are urgently needed.

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