Salubrinal induces fetal hemoglobin expression via the stress-signaling pathway in human sickle erythroid progenitors and sickle cell disease mice

Sickle cell disease (SCD) is an inherited blood disorder caused by a mutation in the HBB gene leading to hemoglobin S production and polymerization under hypoxia conditions leading to vaso-occlusion, chronic hemolysis, and progressive organ damage. This disease affects ~100,000 people in the United...

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Detalles Bibliográficos
Autores principales: Lopez, Nicole H., Li, Biaoru, Palani, Chithra, Siddaramappa, Umapathy, Takezaki, Mayuko, Xu, Hongyan, Zhi, Wenbo, Pace, Betty S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9154101/
https://www.ncbi.nlm.nih.gov/pubmed/35639781
http://dx.doi.org/10.1371/journal.pone.0261799

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9154101/
https://www.ncbi.nlm.nih.gov/pubmed/35639781
http://dx.doi.org/10.1371/journal.pone.0261799

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