Cargando…

Dual 5-HT(3) and 5-HT(6) Receptor Antagonist FPPQ Normalizes Phencyclidine-Induced Disruption of Brain Oscillatory Activity in Rats

Schizophrenia is a severe mental disorder featuring psychotic, depressive, and cognitive alterations. Current antipsychotic drugs preferentially target dopamine D(2)-R and/or serotonergic 5-HT(2A/1A)-R. They partly alleviate psychotic symptoms but fail to treat negative symptoms and cognitive defici...

Descripción completa

Detalles Bibliográficos
Autores principales:	Castañé, Anna, Cano, Montserrat, Ruiz-Avila, Luis, Miquel-Rio, Lluís, Celada, Pau, Artigas, Francesc, Riga, Maurizio S
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Rapid Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9154270/ https://www.ncbi.nlm.nih.gov/pubmed/35022720 http://dx.doi.org/10.1093/ijnp/pyac003

Ejemplares similares

Structure-Based Design and Optimization of FPPQ, a Dual-Acting 5-HT(3) and 5-HT(6) Receptor Antagonist with Antipsychotic and Procognitive Properties
por: Zajdel, Paweł, et al.
Publicado: (2021)

5-HT1A agonists, 5-HT3 antagonists and benzodiazepines : their comparative behavioural pharmacology /
Publicado: (1991)

5-HT3 and 5-HT4 antagonists inhibit peristaltic contractions in guinea-pig distal colon by mechanisms independent of endogenous 5-HT
por: Sia, Tiong C., et al.
Publicado: (2013)

Constitutively Active 5-HT Receptors: An Explanation of How 5-HT Antagonists Inhibit Gut Motility in Species Where 5-HT is Not an Enteric Neurotransmitter?
por: Spencer, Nick J.
Publicado: (2015)

Azologization of serotonin 5-HT(3) receptor antagonists
por: Rustler, Karin, et al.
Publicado: (2019)

Distribution of 5-HT(3), 5-HT(4), and 5-HT(7) Receptors Along the Human Colon
por: Yaakob, Nor S, et al.
Publicado: (2015)

Agonists and antagonists induce different palonosetron dissociation rates in 5-HT(3)A and 5-HT(3)AB receptors()
por: Lummis, Sarah C.R., et al.
Publicado: (2013)

Antidepressant- and Anxiolytic-Like Effects of New Dual 5-HT(1A) and 5-HT(7) Antagonists in Animal Models
por: Pytka, Karolina, et al.
Publicado: (2015)

Review: 5-HT(1), 5-HT(2), 5-HT(3) and 5-HT(7) Receptors and their Role in the Modulation of Pain Response in the Central Nervous System
por: Cortes-Altamirano, Jose Luis, et al.
Publicado: (2018)

Existence of Brain 5-HT1A–5-HT2A Isoreceptor Complexes with Antagonistic Allosteric Receptor–Receptor Interactions Regulating 5-HT1A Receptor Recognition
por: Borroto-Escuela, Dasiel O., et al.
Publicado: (2017)

The muscarinic antagonists scopolamine and atropine are competitive antagonists at 5-HT(3) receptors
por: Lochner, Martin, et al.
Publicado: (2016)

Co-administration of 5-HT6 receptor antagonists with clozapine, risperidone, and a 5-HT2A receptor antagonist: effects on prepulse inhibition in rats
por: Fijał, Katarzyna, et al.
Publicado: (2013)

Superiority of the Triple-Acting 5-HT(6)R/5-HT(3)R Antagonist and MAO-B Reversible Inhibitor PZ-1922 over 5-HT(6)R Antagonist Intepirdine in Alleviation of Cognitive Deficits in Rats
por: Grychowska, Katarzyna, et al.
Publicado: (2023)

Cardiac Roles of Serotonin (5-HT) and 5-HT-Receptors in Health and Disease
por: Neumann, Joachim, et al.
Publicado: (2023)

Conservation of 5-HT(1A) receptor-mediated autoinhibition of serotonin (5-HT) neurons in mice with altered 5-HT homeostasis
por: Araragi, Naozumi, et al.
Publicado: (2013)

Functional group interactions of a 5-HT(3)R antagonist
por: Venkataraman, Padmavati, et al.
Publicado: (2002)

Role of 5-HT(2A) receptor antagonists in the treatment of insomnia
por: Vanover, Kimberly E, et al.
Publicado: (2010)

5HT6 Antagonists in the Treatment of Alzheimer’s Dementia: Current Progress
por: Andrews, Megan, et al.
Publicado: (2018)

Effects of 5‐HT(₃) receptor antagonists on cisplatin‐induced kidney injury
por: Goda, Mitsuhiro, et al.
Publicado: (2021)

Single Administration of HBK-15—a Triple 5-HT(1A), 5-HT(7), and 5-HT(3) Receptor Antagonist—Reverses Depressive-Like Behaviors in Mouse Model of Depression Induced by Corticosterone
por: Pytka, Karolina, et al.
Publicado: (2017)

Human 5–HT(4) and 5–HT(7) Receptor Splice Variants: Are they Important?
por: Coupar, Ian M, et al.
Publicado: (2007)

Discriminating between 5-HT(3)A and 5-HT(3)AB receptors
por: Thompson, AJ, et al.
Publicado: (2013)

Control of Amygdala Circuits by 5-HT Neurons via 5-HT and Glutamate Cotransmission
por: Sengupta, Ayesha, et al.
Publicado: (2017)

5-HT(2A), 5-HT(1B/D), 5HT(3) and 5-HT(7) receptors as mediators of serotonin-induced direct contractile response of bovine airway smooth muscle
por: Da Costa Guevara, Darwin, et al.
Publicado: (2021)

Regulatory mechanism of CCN2 production by serotonin (5-HT) via 5-HT(2A) and 5-HT(2B) receptors in chondrocytes
por: Hori, Ayaka, et al.
Publicado: (2017)

Reduction of the serotonin 5-HT(1B) and 5-HT(2A) receptor-mediated contraction of human pulmonary artery by the combined 5-HT(1B) receptor antagonist and serotonin transporter inhibitor LY393558
por: Baranowska-Kuczko, Marta, et al.
Publicado: (2020)

5-HT(3) Receptors
por: Lummis, Sarah C. R.
Publicado: (2012)

5-HT and Intraplatelet 5-HT: a potential upstream regulator of YAP in liver regeneration
por: He, Chao, et al.
Publicado: (2019)

Patient perceptions of the side-effects of chemotherapy: the influence of 5HT3 antagonists.
por: de Boer-Dennert, M., et al.
Publicado: (1997)

Distribution of cells responsive to 5-HT(6) receptor antagonist-induced hypophagia
por: Garfield, Alastair S., et al.
Publicado: (2014)

Recent advances in antiemetics: new formulations of 5HT(3)-receptor antagonists
por: Gilmore, James, et al.
Publicado: (2018)

Serotonin 5-HT3 Receptor Antagonist for Treatment of Severe Diabetic Diarrhea
por: Murao, Satoshi, et al.
Publicado: (2010)

Selective 5HT3 antagonists and sensory processing: a systematic review
por: Tsitsipa, Eirini, et al.
Publicado: (2022)

Differential Patterns of Subcortical Activity Evoked by Glial GLT-1 Blockade in Prelimbic and Infralimbic Cortex: Relationship to Antidepressant-Like Effects in Rats
por: Gasull-Camós, Júlia, et al.
Publicado: (2017)

Involvement of NMDA receptors containing the GluN2C subunit in the psychotomimetic and antidepressant-like effects of ketamine
por: Tarrés-Gatius, Mireia, et al.
Publicado: (2020)

Anxiolytic-like effects observed in rats exposed to the elevated zero-maze following treatment with 5-HT(2)/5-HT(3)/5-HT(4) ligands
por: Bell, Rob, et al.
Publicado: (2014)

Expression Patterns of Serotonin Receptors 5-HT1A, 5-HT2A, and 5-HT3A during Human Fetal Lung Development
por: Nikolić, Jelena, et al.
Publicado: (2023)

Endogenous 5-HT outflow from chicken aorta by 5-HT uptake inhibitors and amphetamine derivatives
por: DELGERMURUN, Dugar, et al.
Publicado: (2015)

Biophysical validation of serotonin 5-HT(2A) and 5-HT(2C) receptor interaction
por: Felsing, Daniel E., et al.
Publicado: (2018)

The 5-HT(2C) receptor agonist, lorcaserin, and the 5-HT(6) receptor antagonist, SB-742457, promote satiety; a microstructural analysis of feeding behaviour
por: Higgs, Suzanne, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_5bt1kh53oh5mqse916i28gmbff