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Diet high in branched-chain amino acid promotes PDAC development by USP1-mediated BCAT2 stabilization

BCAT2-mediated branched-chain amino acid (BCAA) catabolism is critical for pancreatic ductal adenocarcinoma (PDAC) development, especially at an early stage. However, whether a high-BCAA diet promotes PDAC development in vivo, and the underlying mechanism of BCAT2 upregulation, remain undefined. Her...

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Detalles Bibliográficos
Autores principales:	Li, Jin-Tao, Li, Kai-Yue, Su, Ying, Shen, Yuan, Lei, Ming-Zhu, Zhang, Fan, Yin, Miao, Chen, Zheng-Jun, Wen, Wen-Yu, Hu, Wei-Guo, Su, Dan, Qu, Jia, Lei, Qun-Ying
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9154341/ https://www.ncbi.nlm.nih.gov/pubmed/35663242 http://dx.doi.org/10.1093/nsr/nwab212

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