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Endothelial Progenitor Cells in Coronary Artery Disease: From Bench to Bedside

Endothelial progenitor cells (EPCs) are a heterogeneous group of cells present in peripheral blood at various stages of endothelial differentiation. EPCs have been extensively investigated in patients with coronary artery disease (CAD), with controversial findings both on their role in atheroscleros...

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Autores principales: Pelliccia, Francesco, Zimarino, Marco, De Luca, Giuseppe, Viceconte, Nicola, Tanzilli, Gaetano, De Caterina, Raffaele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9154346/
https://www.ncbi.nlm.nih.gov/pubmed/35365823
http://dx.doi.org/10.1093/stcltm/szac010
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author Pelliccia, Francesco
Zimarino, Marco
De Luca, Giuseppe
Viceconte, Nicola
Tanzilli, Gaetano
De Caterina, Raffaele
author_facet Pelliccia, Francesco
Zimarino, Marco
De Luca, Giuseppe
Viceconte, Nicola
Tanzilli, Gaetano
De Caterina, Raffaele
author_sort Pelliccia, Francesco
collection PubMed
description Endothelial progenitor cells (EPCs) are a heterogeneous group of cells present in peripheral blood at various stages of endothelial differentiation. EPCs have been extensively investigated in patients with coronary artery disease (CAD), with controversial findings both on their role in atherosclerosis progression and in the process of neointimal growth after a percutaneous coronary intervention (PCI). Despite nearly 2 decades of experimental and clinical investigations, however, the significance of EPCs in clinical practice remains unclear and poorly understood. This review provides an update on the role of EPCs in the most common clinical scenarios that are experienced by cardiologists managing patients with CAD. We here summarize the main findings on the association of EPCs with cardiovascular risk factors, coronary atherosclerosis, and myocardial ischemia. We then discuss the potential effects of EPCs in post-PCI in-stent restenosis, as well as most recent findings with EPC-coated stents. Based on the mounting evidence of the relationship between levels of EPCs and several different adverse cardiovascular events, EPCs are emerging as novel predictive biomarkers of long-term outcomes in patients with CAD.
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spelling pubmed-91543462022-06-04 Endothelial Progenitor Cells in Coronary Artery Disease: From Bench to Bedside Pelliccia, Francesco Zimarino, Marco De Luca, Giuseppe Viceconte, Nicola Tanzilli, Gaetano De Caterina, Raffaele Stem Cells Transl Med Human Clinical Articles Endothelial progenitor cells (EPCs) are a heterogeneous group of cells present in peripheral blood at various stages of endothelial differentiation. EPCs have been extensively investigated in patients with coronary artery disease (CAD), with controversial findings both on their role in atherosclerosis progression and in the process of neointimal growth after a percutaneous coronary intervention (PCI). Despite nearly 2 decades of experimental and clinical investigations, however, the significance of EPCs in clinical practice remains unclear and poorly understood. This review provides an update on the role of EPCs in the most common clinical scenarios that are experienced by cardiologists managing patients with CAD. We here summarize the main findings on the association of EPCs with cardiovascular risk factors, coronary atherosclerosis, and myocardial ischemia. We then discuss the potential effects of EPCs in post-PCI in-stent restenosis, as well as most recent findings with EPC-coated stents. Based on the mounting evidence of the relationship between levels of EPCs and several different adverse cardiovascular events, EPCs are emerging as novel predictive biomarkers of long-term outcomes in patients with CAD. Oxford University Press 2022-04-01 /pmc/articles/PMC9154346/ /pubmed/35365823 http://dx.doi.org/10.1093/stcltm/szac010 Text en © The Author(s) 2022. Published by Oxford University Press. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Human Clinical Articles
Pelliccia, Francesco
Zimarino, Marco
De Luca, Giuseppe
Viceconte, Nicola
Tanzilli, Gaetano
De Caterina, Raffaele
Endothelial Progenitor Cells in Coronary Artery Disease: From Bench to Bedside
title Endothelial Progenitor Cells in Coronary Artery Disease: From Bench to Bedside
title_full Endothelial Progenitor Cells in Coronary Artery Disease: From Bench to Bedside
title_fullStr Endothelial Progenitor Cells in Coronary Artery Disease: From Bench to Bedside
title_full_unstemmed Endothelial Progenitor Cells in Coronary Artery Disease: From Bench to Bedside
title_short Endothelial Progenitor Cells in Coronary Artery Disease: From Bench to Bedside
title_sort endothelial progenitor cells in coronary artery disease: from bench to bedside
topic Human Clinical Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9154346/
https://www.ncbi.nlm.nih.gov/pubmed/35365823
http://dx.doi.org/10.1093/stcltm/szac010
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