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Recent advances in anti-multidrug resistance for nano-drug delivery system

Chemotherapy for tumors occasionally results in drug resistance, which is the major reason for the treatment failure. Higher drug doses could improve the therapeutic effect, but higher toxicity limits the further treatment. For overcoming drug resistance, functional nano-drug delivery system (NDDS)...

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Detalles Bibliográficos
Autores principales: Wang, Changduo, Li, Fashun, Zhang, Tianao, Yu, Min, Sun, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9154776/
https://www.ncbi.nlm.nih.gov/pubmed/35616278
http://dx.doi.org/10.1080/10717544.2022.2079771
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author Wang, Changduo
Li, Fashun
Zhang, Tianao
Yu, Min
Sun, Yong
author_facet Wang, Changduo
Li, Fashun
Zhang, Tianao
Yu, Min
Sun, Yong
author_sort Wang, Changduo
collection PubMed
description Chemotherapy for tumors occasionally results in drug resistance, which is the major reason for the treatment failure. Higher drug doses could improve the therapeutic effect, but higher toxicity limits the further treatment. For overcoming drug resistance, functional nano-drug delivery system (NDDS) has been explored to sensitize the anticancer drugs and decrease its side effects, which are applied in combating multidrug resistance (MDR) via a variety of mechanisms including bypassing drug efflux, controlling drug release, and disturbing metabolism. This review starts with a brief report on the major MDR causes. Furthermore, we searched the papers from NDDS and introduced the recent advances in sensitizing the chemotherapeutic drugs against MDR tumors. Finally, we concluded that the NDDS was based on several mechanisms, and we looked forward to the future in this field.
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spelling pubmed-91547762022-06-01 Recent advances in anti-multidrug resistance for nano-drug delivery system Wang, Changduo Li, Fashun Zhang, Tianao Yu, Min Sun, Yong Drug Deliv Research Articles Chemotherapy for tumors occasionally results in drug resistance, which is the major reason for the treatment failure. Higher drug doses could improve the therapeutic effect, but higher toxicity limits the further treatment. For overcoming drug resistance, functional nano-drug delivery system (NDDS) has been explored to sensitize the anticancer drugs and decrease its side effects, which are applied in combating multidrug resistance (MDR) via a variety of mechanisms including bypassing drug efflux, controlling drug release, and disturbing metabolism. This review starts with a brief report on the major MDR causes. Furthermore, we searched the papers from NDDS and introduced the recent advances in sensitizing the chemotherapeutic drugs against MDR tumors. Finally, we concluded that the NDDS was based on several mechanisms, and we looked forward to the future in this field. Taylor & Francis 2022-05-26 /pmc/articles/PMC9154776/ /pubmed/35616278 http://dx.doi.org/10.1080/10717544.2022.2079771 Text en © 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Wang, Changduo
Li, Fashun
Zhang, Tianao
Yu, Min
Sun, Yong
Recent advances in anti-multidrug resistance for nano-drug delivery system
title Recent advances in anti-multidrug resistance for nano-drug delivery system
title_full Recent advances in anti-multidrug resistance for nano-drug delivery system
title_fullStr Recent advances in anti-multidrug resistance for nano-drug delivery system
title_full_unstemmed Recent advances in anti-multidrug resistance for nano-drug delivery system
title_short Recent advances in anti-multidrug resistance for nano-drug delivery system
title_sort recent advances in anti-multidrug resistance for nano-drug delivery system
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9154776/
https://www.ncbi.nlm.nih.gov/pubmed/35616278
http://dx.doi.org/10.1080/10717544.2022.2079771
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