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Recent advances in anti-multidrug resistance for nano-drug delivery system
Chemotherapy for tumors occasionally results in drug resistance, which is the major reason for the treatment failure. Higher drug doses could improve the therapeutic effect, but higher toxicity limits the further treatment. For overcoming drug resistance, functional nano-drug delivery system (NDDS)...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9154776/ https://www.ncbi.nlm.nih.gov/pubmed/35616278 http://dx.doi.org/10.1080/10717544.2022.2079771 |
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author | Wang, Changduo Li, Fashun Zhang, Tianao Yu, Min Sun, Yong |
author_facet | Wang, Changduo Li, Fashun Zhang, Tianao Yu, Min Sun, Yong |
author_sort | Wang, Changduo |
collection | PubMed |
description | Chemotherapy for tumors occasionally results in drug resistance, which is the major reason for the treatment failure. Higher drug doses could improve the therapeutic effect, but higher toxicity limits the further treatment. For overcoming drug resistance, functional nano-drug delivery system (NDDS) has been explored to sensitize the anticancer drugs and decrease its side effects, which are applied in combating multidrug resistance (MDR) via a variety of mechanisms including bypassing drug efflux, controlling drug release, and disturbing metabolism. This review starts with a brief report on the major MDR causes. Furthermore, we searched the papers from NDDS and introduced the recent advances in sensitizing the chemotherapeutic drugs against MDR tumors. Finally, we concluded that the NDDS was based on several mechanisms, and we looked forward to the future in this field. |
format | Online Article Text |
id | pubmed-9154776 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-91547762022-06-01 Recent advances in anti-multidrug resistance for nano-drug delivery system Wang, Changduo Li, Fashun Zhang, Tianao Yu, Min Sun, Yong Drug Deliv Research Articles Chemotherapy for tumors occasionally results in drug resistance, which is the major reason for the treatment failure. Higher drug doses could improve the therapeutic effect, but higher toxicity limits the further treatment. For overcoming drug resistance, functional nano-drug delivery system (NDDS) has been explored to sensitize the anticancer drugs and decrease its side effects, which are applied in combating multidrug resistance (MDR) via a variety of mechanisms including bypassing drug efflux, controlling drug release, and disturbing metabolism. This review starts with a brief report on the major MDR causes. Furthermore, we searched the papers from NDDS and introduced the recent advances in sensitizing the chemotherapeutic drugs against MDR tumors. Finally, we concluded that the NDDS was based on several mechanisms, and we looked forward to the future in this field. Taylor & Francis 2022-05-26 /pmc/articles/PMC9154776/ /pubmed/35616278 http://dx.doi.org/10.1080/10717544.2022.2079771 Text en © 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Articles Wang, Changduo Li, Fashun Zhang, Tianao Yu, Min Sun, Yong Recent advances in anti-multidrug resistance for nano-drug delivery system |
title | Recent advances in anti-multidrug resistance for nano-drug delivery system |
title_full | Recent advances in anti-multidrug resistance for nano-drug delivery system |
title_fullStr | Recent advances in anti-multidrug resistance for nano-drug delivery system |
title_full_unstemmed | Recent advances in anti-multidrug resistance for nano-drug delivery system |
title_short | Recent advances in anti-multidrug resistance for nano-drug delivery system |
title_sort | recent advances in anti-multidrug resistance for nano-drug delivery system |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9154776/ https://www.ncbi.nlm.nih.gov/pubmed/35616278 http://dx.doi.org/10.1080/10717544.2022.2079771 |
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