N(6)-methyladenosine–modified RNA acts as a molecular glue that drives liquid–liquid phase separation in plants

Liquid-like condensates are organized by multivalent intrinsically disordered proteins and RNA molecules. We here demonstrate that N(6)-methyladenosine (m(6)A)-modified RNA is widespread in establishing diverse plant cell condensates. Several m(6)A-reader proteins contain putative prion-like domains...

Descripción completa

Detalles Bibliográficos
Autores principales: Lee, Hong Gil, Kim, Jiwoo, Seo, Pil Joon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9154792/
https://www.ncbi.nlm.nih.gov/pubmed/35621186
http://dx.doi.org/10.1080/15592324.2022.2079308
_version_ 1784718106408517632
author Lee, Hong Gil
Kim, Jiwoo
Seo, Pil Joon
author_facet Lee, Hong Gil
Kim, Jiwoo
Seo, Pil Joon
author_sort Lee, Hong Gil
collection PubMed
description Liquid-like condensates are organized by multivalent intrinsically disordered proteins and RNA molecules. We here demonstrate that N(6)-methyladenosine (m(6)A)-modified RNA is widespread in establishing diverse plant cell condensates. Several m(6)A-reader proteins contain putative prion-like domains, and the ect2/3/4 mutant exhibited reduced formation of key nuclear and cytoplasmic condensates in Arabidopsis.
format Online
Article
Text
id pubmed-9154792
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Taylor & Francis
record_format MEDLINE/PubMed
spelling pubmed-91547922022-06-01 N(6)-methyladenosine–modified RNA acts as a molecular glue that drives liquid–liquid phase separation in plants Lee, Hong Gil Kim, Jiwoo Seo, Pil Joon Plant Signal Behav Short Communication Liquid-like condensates are organized by multivalent intrinsically disordered proteins and RNA molecules. We here demonstrate that N(6)-methyladenosine (m(6)A)-modified RNA is widespread in establishing diverse plant cell condensates. Several m(6)A-reader proteins contain putative prion-like domains, and the ect2/3/4 mutant exhibited reduced formation of key nuclear and cytoplasmic condensates in Arabidopsis. Taylor & Francis 2022-05-27 /pmc/articles/PMC9154792/ /pubmed/35621186 http://dx.doi.org/10.1080/15592324.2022.2079308 Text en © 2022 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communication
Lee, Hong Gil
Kim, Jiwoo
Seo, Pil Joon
N(6)-methyladenosine–modified RNA acts as a molecular glue that drives liquid–liquid phase separation in plants
title N(6)-methyladenosine–modified RNA acts as a molecular glue that drives liquid–liquid phase separation in plants
title_full N(6)-methyladenosine–modified RNA acts as a molecular glue that drives liquid–liquid phase separation in plants
title_fullStr N(6)-methyladenosine–modified RNA acts as a molecular glue that drives liquid–liquid phase separation in plants
title_full_unstemmed N(6)-methyladenosine–modified RNA acts as a molecular glue that drives liquid–liquid phase separation in plants
title_short N(6)-methyladenosine–modified RNA acts as a molecular glue that drives liquid–liquid phase separation in plants
title_sort n(6)-methyladenosine–modified rna acts as a molecular glue that drives liquid–liquid phase separation in plants
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9154792/
https://www.ncbi.nlm.nih.gov/pubmed/35621186
http://dx.doi.org/10.1080/15592324.2022.2079308
work_keys_str_mv AT leehonggil n6methyladenosinemodifiedrnaactsasamoleculargluethatdrivesliquidliquidphaseseparationinplants
AT kimjiwoo n6methyladenosinemodifiedrnaactsasamoleculargluethatdrivesliquidliquidphaseseparationinplants
AT seopiljoon n6methyladenosinemodifiedrnaactsasamoleculargluethatdrivesliquidliquidphaseseparationinplants

Ejemplares similares