Virus replication and competition in a cell culture: Application to the SARS-CoV-2 variants

Viral replication in a cell culture is described by a delay reaction–diffusion system. It is shown that infection spreads in cell culture as a reaction–diffusion wave, for which the speed of propagation and viral load can be determined both analytically and numerically. Competition of two virus vari...

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Autores principales: Ait Mahiout, L., Mozokhina, A., Tokarev, A., Volpert, V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9155187/
https://www.ncbi.nlm.nih.gov/pubmed/35669092
http://dx.doi.org/10.1016/j.aml.2022.108217
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author Ait Mahiout, L.
Mozokhina, A.
Tokarev, A.
Volpert, V.
author_facet Ait Mahiout, L.
Mozokhina, A.
Tokarev, A.
Volpert, V.
author_sort Ait Mahiout, L.
collection PubMed
description Viral replication in a cell culture is described by a delay reaction–diffusion system. It is shown that infection spreads in cell culture as a reaction–diffusion wave, for which the speed of propagation and viral load can be determined both analytically and numerically. Competition of two virus variants in the same cell culture is studied, and it is shown that the variant with larger individual wave speed out-competes another one, and eliminates it. This approach is applied to the Delta and Omicron variants of the SARS-CoV-2 infection in the cultures of human epithelial and lung cells, allowing characterization of infectivity and virulence of each variant, and their comparison.
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spelling pubmed-91551872022-06-02 Virus replication and competition in a cell culture: Application to the SARS-CoV-2 variants Ait Mahiout, L. Mozokhina, A. Tokarev, A. Volpert, V. Appl Math Lett Article Viral replication in a cell culture is described by a delay reaction–diffusion system. It is shown that infection spreads in cell culture as a reaction–diffusion wave, for which the speed of propagation and viral load can be determined both analytically and numerically. Competition of two virus variants in the same cell culture is studied, and it is shown that the variant with larger individual wave speed out-competes another one, and eliminates it. This approach is applied to the Delta and Omicron variants of the SARS-CoV-2 infection in the cultures of human epithelial and lung cells, allowing characterization of infectivity and virulence of each variant, and their comparison. Elsevier Ltd. 2022-11 2022-05-31 /pmc/articles/PMC9155187/ /pubmed/35669092 http://dx.doi.org/10.1016/j.aml.2022.108217 Text en © 2022 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Ait Mahiout, L.
Mozokhina, A.
Tokarev, A.
Volpert, V.
Virus replication and competition in a cell culture: Application to the SARS-CoV-2 variants
title Virus replication and competition in a cell culture: Application to the SARS-CoV-2 variants
title_full Virus replication and competition in a cell culture: Application to the SARS-CoV-2 variants
title_fullStr Virus replication and competition in a cell culture: Application to the SARS-CoV-2 variants
title_full_unstemmed Virus replication and competition in a cell culture: Application to the SARS-CoV-2 variants
title_short Virus replication and competition in a cell culture: Application to the SARS-CoV-2 variants
title_sort virus replication and competition in a cell culture: application to the sars-cov-2 variants
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9155187/
https://www.ncbi.nlm.nih.gov/pubmed/35669092
http://dx.doi.org/10.1016/j.aml.2022.108217
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