Proposed Linezolid Dosing Strategies to Minimize Adverse Events for Treatment of Extensively Drug-Resistant Tuberculosis

BACKGROUND: We evaluated Nix-TB trial data (NCT02333799, N = 109) to provide dosing recommendations to potentially minimize linezolid toxicity in patients with extensively drug-resistant tuberculosis. . METHODS: A pharmacokinetic model and toxicodynamic models for peripheral neuropathy, hemoglobin,...

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Detalles Bibliográficos
Autores principales: Imperial, Marjorie Z, Nedelman, Jerry R, Conradie, Francesca, Savic, R M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Major Articles and Commentaries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9155613/
https://www.ncbi.nlm.nih.gov/pubmed/34604901
http://dx.doi.org/10.1093/cid/ciab699

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9155613/
https://www.ncbi.nlm.nih.gov/pubmed/34604901
http://dx.doi.org/10.1093/cid/ciab699

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