Expansion of L452R-Positive SARS-CoV-2 Omicron Variant, Northern Lombardy, Italy

We report 25 cases of infection with SARS-CoV-2 Omicron variant containing spike protein L452R mutation in northern Lombardy, Italy. Prevalence of this variant was >30% in this region, compared with <0.5% worldwide. Many laboratories are using previously developed L452R-specific PCRs to discri...

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Detalles Bibliográficos
Autores principales: Novazzi, Federica, Baj, Andreina, Genoni, Angelo, Focosi, Daniele, Maggi, Fabrizio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2022
Materias:
Research Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9155861/
https://www.ncbi.nlm.nih.gov/pubmed/35416767
http://dx.doi.org/10.3201/eid2806.220210
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author Novazzi, Federica
Baj, Andreina
Genoni, Angelo
Focosi, Daniele
Maggi, Fabrizio
author_facet Novazzi, Federica
Baj, Andreina
Genoni, Angelo
Focosi, Daniele
Maggi, Fabrizio
author_sort Novazzi, Federica
collection PubMed
description We report 25 cases of infection with SARS-CoV-2 Omicron variant containing spike protein L452R mutation in northern Lombardy, Italy. Prevalence of this variant was >30% in this region, compared with <0.5% worldwide. Many laboratories are using previously developed L452R-specific PCRs to discriminate Omicron from Delta mutations, but these tests may be unreliable.
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spelling pubmed-91558612022-06-04 Expansion of L452R-Positive SARS-CoV-2 Omicron Variant, Northern Lombardy, Italy Novazzi, Federica Baj, Andreina Genoni, Angelo Focosi, Daniele Maggi, Fabrizio Emerg Infect Dis Research Letter We report 25 cases of infection with SARS-CoV-2 Omicron variant containing spike protein L452R mutation in northern Lombardy, Italy. Prevalence of this variant was >30% in this region, compared with <0.5% worldwide. Many laboratories are using previously developed L452R-specific PCRs to discriminate Omicron from Delta mutations, but these tests may be unreliable. Centers for Disease Control and Prevention 2022-06 /pmc/articles/PMC9155861/ /pubmed/35416767 http://dx.doi.org/10.3201/eid2806.220210 Text en https://creativecommons.org/licenses/by/4.0/Emerging Infectious Diseases is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Research Letter
Novazzi, Federica
Baj, Andreina
Genoni, Angelo
Focosi, Daniele
Maggi, Fabrizio
Expansion of L452R-Positive SARS-CoV-2 Omicron Variant, Northern Lombardy, Italy
title Expansion of L452R-Positive SARS-CoV-2 Omicron Variant, Northern Lombardy, Italy
title_full Expansion of L452R-Positive SARS-CoV-2 Omicron Variant, Northern Lombardy, Italy
title_fullStr Expansion of L452R-Positive SARS-CoV-2 Omicron Variant, Northern Lombardy, Italy
title_full_unstemmed Expansion of L452R-Positive SARS-CoV-2 Omicron Variant, Northern Lombardy, Italy
title_short Expansion of L452R-Positive SARS-CoV-2 Omicron Variant, Northern Lombardy, Italy
title_sort expansion of l452r-positive sars-cov-2 omicron variant, northern lombardy, italy
topic Research Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9155861/
https://www.ncbi.nlm.nih.gov/pubmed/35416767
http://dx.doi.org/10.3201/eid2806.220210
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