The Regulation and Characterization of Mitochondrial-Derived Methylmalonic Acid in Mitochondrial Dysfunction and Oxidative Stress: From Basic Research to Clinical Practice

Methylmalonic acid (MMA) can act as a diagnosis of hereditary methylmalonic acidemia and assess the status of vitamin B12. Moreover, as a new potential biomarker, it has been widely reported to be associated with the progression and prognosis of chronic diseases such as cardiovascular events, renal...

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Autores principales: Liu, Yige, Wang, Shanjie, Zhang, Xiaoyuan, Cai, Hengxuan, Liu, Jinxin, Fang, Shaohong, Yu, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9155905/
https://www.ncbi.nlm.nih.gov/pubmed/35656023
http://dx.doi.org/10.1155/2022/7043883
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author Liu, Yige
Wang, Shanjie
Zhang, Xiaoyuan
Cai, Hengxuan
Liu, Jinxin
Fang, Shaohong
Yu, Bo
author_facet Liu, Yige
Wang, Shanjie
Zhang, Xiaoyuan
Cai, Hengxuan
Liu, Jinxin
Fang, Shaohong
Yu, Bo
author_sort Liu, Yige
collection PubMed
description Methylmalonic acid (MMA) can act as a diagnosis of hereditary methylmalonic acidemia and assess the status of vitamin B12. Moreover, as a new potential biomarker, it has been widely reported to be associated with the progression and prognosis of chronic diseases such as cardiovascular events, renal insufficiency, cognitive impairment, and cancer. MMA accumulation may cause oxidative stress and impair mitochondrial function, disrupt cellular energy metabolism, and trigger cell death. This review primarily focuses on the mechanisms and epidemiology or progression in the clinical study on MMA.
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spelling pubmed-91559052022-06-01 The Regulation and Characterization of Mitochondrial-Derived Methylmalonic Acid in Mitochondrial Dysfunction and Oxidative Stress: From Basic Research to Clinical Practice Liu, Yige Wang, Shanjie Zhang, Xiaoyuan Cai, Hengxuan Liu, Jinxin Fang, Shaohong Yu, Bo Oxid Med Cell Longev Review Article Methylmalonic acid (MMA) can act as a diagnosis of hereditary methylmalonic acidemia and assess the status of vitamin B12. Moreover, as a new potential biomarker, it has been widely reported to be associated with the progression and prognosis of chronic diseases such as cardiovascular events, renal insufficiency, cognitive impairment, and cancer. MMA accumulation may cause oxidative stress and impair mitochondrial function, disrupt cellular energy metabolism, and trigger cell death. This review primarily focuses on the mechanisms and epidemiology or progression in the clinical study on MMA. Hindawi 2022-05-24 /pmc/articles/PMC9155905/ /pubmed/35656023 http://dx.doi.org/10.1155/2022/7043883 Text en Copyright © 2022 Yige Liu et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Liu, Yige
Wang, Shanjie
Zhang, Xiaoyuan
Cai, Hengxuan
Liu, Jinxin
Fang, Shaohong
Yu, Bo
The Regulation and Characterization of Mitochondrial-Derived Methylmalonic Acid in Mitochondrial Dysfunction and Oxidative Stress: From Basic Research to Clinical Practice
title The Regulation and Characterization of Mitochondrial-Derived Methylmalonic Acid in Mitochondrial Dysfunction and Oxidative Stress: From Basic Research to Clinical Practice
title_full The Regulation and Characterization of Mitochondrial-Derived Methylmalonic Acid in Mitochondrial Dysfunction and Oxidative Stress: From Basic Research to Clinical Practice
title_fullStr The Regulation and Characterization of Mitochondrial-Derived Methylmalonic Acid in Mitochondrial Dysfunction and Oxidative Stress: From Basic Research to Clinical Practice
title_full_unstemmed The Regulation and Characterization of Mitochondrial-Derived Methylmalonic Acid in Mitochondrial Dysfunction and Oxidative Stress: From Basic Research to Clinical Practice
title_short The Regulation and Characterization of Mitochondrial-Derived Methylmalonic Acid in Mitochondrial Dysfunction and Oxidative Stress: From Basic Research to Clinical Practice
title_sort regulation and characterization of mitochondrial-derived methylmalonic acid in mitochondrial dysfunction and oxidative stress: from basic research to clinical practice
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9155905/
https://www.ncbi.nlm.nih.gov/pubmed/35656023
http://dx.doi.org/10.1155/2022/7043883
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