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Neurobehavioral and Biochemical Evidences in Support of Protective Effect of Marrubiin (Furan Labdane Diterpene) from Marrubium vulgare Linn. and Its Extracts after Traumatic Brain Injury in Experimental Mice

Traumatic brain injuries due to sudden accidents cause major physical and mental health problems and are one of the main reasons behind the mortality and disability of patients. Research on alternate natural sources could be a boon for the rehabilitation of poor TBI patients. The literature indicate...

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Autores principales: Nidhi, Singh, Govind, Valecha, Rekha, Shukla, Govind, Kaushik, Deepak, Rahman, Mohammad Akhlaquer, Gautam, Rupesh K., Madan, Kumud, Mittal, Vineet, Singla, Rajeev K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9155918/
https://www.ncbi.nlm.nih.gov/pubmed/35656476
http://dx.doi.org/10.1155/2022/4457973
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author Nidhi,
Singh, Govind
Valecha, Rekha
Shukla, Govind
Kaushik, Deepak
Rahman, Mohammad Akhlaquer
Gautam, Rupesh K.
Madan, Kumud
Mittal, Vineet
Singla, Rajeev K.
author_facet Nidhi,
Singh, Govind
Valecha, Rekha
Shukla, Govind
Kaushik, Deepak
Rahman, Mohammad Akhlaquer
Gautam, Rupesh K.
Madan, Kumud
Mittal, Vineet
Singla, Rajeev K.
author_sort Nidhi,
collection PubMed
description Traumatic brain injuries due to sudden accidents cause major physical and mental health problems and are one of the main reasons behind the mortality and disability of patients. Research on alternate natural sources could be a boon for the rehabilitation of poor TBI patients. The literature indicates the Marrubium vulgare Linn. and its secondary metabolite marrubiin (furan labdane diterpene) possess various pharmacological properties such as vasorelaxant, calcium channel blocker, antioxidant, and antiedematogenic activities. Hence, in the present research, both marrubiin and hydroalcoholic extracts of the plant were evaluated for their neuroprotective effect after TBI. The neurological severity score and oxidative stress parameters are significantly altered by the test samples. Moreover, the neurotransmitter analysis indicated a significant change in GABA and glutamate. The histopathological study also supported the observed results. The improved neuroprotective potential of the extract could be attributed to the presence of a large number of secondary metabolites including marrubiin.
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spelling pubmed-91559182022-06-01 Neurobehavioral and Biochemical Evidences in Support of Protective Effect of Marrubiin (Furan Labdane Diterpene) from Marrubium vulgare Linn. and Its Extracts after Traumatic Brain Injury in Experimental Mice Nidhi, Singh, Govind Valecha, Rekha Shukla, Govind Kaushik, Deepak Rahman, Mohammad Akhlaquer Gautam, Rupesh K. Madan, Kumud Mittal, Vineet Singla, Rajeev K. Evid Based Complement Alternat Med Research Article Traumatic brain injuries due to sudden accidents cause major physical and mental health problems and are one of the main reasons behind the mortality and disability of patients. Research on alternate natural sources could be a boon for the rehabilitation of poor TBI patients. The literature indicates the Marrubium vulgare Linn. and its secondary metabolite marrubiin (furan labdane diterpene) possess various pharmacological properties such as vasorelaxant, calcium channel blocker, antioxidant, and antiedematogenic activities. Hence, in the present research, both marrubiin and hydroalcoholic extracts of the plant were evaluated for their neuroprotective effect after TBI. The neurological severity score and oxidative stress parameters are significantly altered by the test samples. Moreover, the neurotransmitter analysis indicated a significant change in GABA and glutamate. The histopathological study also supported the observed results. The improved neuroprotective potential of the extract could be attributed to the presence of a large number of secondary metabolites including marrubiin. Hindawi 2022-05-24 /pmc/articles/PMC9155918/ /pubmed/35656476 http://dx.doi.org/10.1155/2022/4457973 Text en Copyright © 2022 Nidhi et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Nidhi,
Singh, Govind
Valecha, Rekha
Shukla, Govind
Kaushik, Deepak
Rahman, Mohammad Akhlaquer
Gautam, Rupesh K.
Madan, Kumud
Mittal, Vineet
Singla, Rajeev K.
Neurobehavioral and Biochemical Evidences in Support of Protective Effect of Marrubiin (Furan Labdane Diterpene) from Marrubium vulgare Linn. and Its Extracts after Traumatic Brain Injury in Experimental Mice
title Neurobehavioral and Biochemical Evidences in Support of Protective Effect of Marrubiin (Furan Labdane Diterpene) from Marrubium vulgare Linn. and Its Extracts after Traumatic Brain Injury in Experimental Mice
title_full Neurobehavioral and Biochemical Evidences in Support of Protective Effect of Marrubiin (Furan Labdane Diterpene) from Marrubium vulgare Linn. and Its Extracts after Traumatic Brain Injury in Experimental Mice
title_fullStr Neurobehavioral and Biochemical Evidences in Support of Protective Effect of Marrubiin (Furan Labdane Diterpene) from Marrubium vulgare Linn. and Its Extracts after Traumatic Brain Injury in Experimental Mice
title_full_unstemmed Neurobehavioral and Biochemical Evidences in Support of Protective Effect of Marrubiin (Furan Labdane Diterpene) from Marrubium vulgare Linn. and Its Extracts after Traumatic Brain Injury in Experimental Mice
title_short Neurobehavioral and Biochemical Evidences in Support of Protective Effect of Marrubiin (Furan Labdane Diterpene) from Marrubium vulgare Linn. and Its Extracts after Traumatic Brain Injury in Experimental Mice
title_sort neurobehavioral and biochemical evidences in support of protective effect of marrubiin (furan labdane diterpene) from marrubium vulgare linn. and its extracts after traumatic brain injury in experimental mice
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9155918/
https://www.ncbi.nlm.nih.gov/pubmed/35656476
http://dx.doi.org/10.1155/2022/4457973
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