Cargando…
Neurobehavioral and Biochemical Evidences in Support of Protective Effect of Marrubiin (Furan Labdane Diterpene) from Marrubium vulgare Linn. and Its Extracts after Traumatic Brain Injury in Experimental Mice
Traumatic brain injuries due to sudden accidents cause major physical and mental health problems and are one of the main reasons behind the mortality and disability of patients. Research on alternate natural sources could be a boon for the rehabilitation of poor TBI patients. The literature indicate...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9155918/ https://www.ncbi.nlm.nih.gov/pubmed/35656476 http://dx.doi.org/10.1155/2022/4457973 |
_version_ | 1784718339387424768 |
---|---|
author | Nidhi, Singh, Govind Valecha, Rekha Shukla, Govind Kaushik, Deepak Rahman, Mohammad Akhlaquer Gautam, Rupesh K. Madan, Kumud Mittal, Vineet Singla, Rajeev K. |
author_facet | Nidhi, Singh, Govind Valecha, Rekha Shukla, Govind Kaushik, Deepak Rahman, Mohammad Akhlaquer Gautam, Rupesh K. Madan, Kumud Mittal, Vineet Singla, Rajeev K. |
author_sort | Nidhi, |
collection | PubMed |
description | Traumatic brain injuries due to sudden accidents cause major physical and mental health problems and are one of the main reasons behind the mortality and disability of patients. Research on alternate natural sources could be a boon for the rehabilitation of poor TBI patients. The literature indicates the Marrubium vulgare Linn. and its secondary metabolite marrubiin (furan labdane diterpene) possess various pharmacological properties such as vasorelaxant, calcium channel blocker, antioxidant, and antiedematogenic activities. Hence, in the present research, both marrubiin and hydroalcoholic extracts of the plant were evaluated for their neuroprotective effect after TBI. The neurological severity score and oxidative stress parameters are significantly altered by the test samples. Moreover, the neurotransmitter analysis indicated a significant change in GABA and glutamate. The histopathological study also supported the observed results. The improved neuroprotective potential of the extract could be attributed to the presence of a large number of secondary metabolites including marrubiin. |
format | Online Article Text |
id | pubmed-9155918 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-91559182022-06-01 Neurobehavioral and Biochemical Evidences in Support of Protective Effect of Marrubiin (Furan Labdane Diterpene) from Marrubium vulgare Linn. and Its Extracts after Traumatic Brain Injury in Experimental Mice Nidhi, Singh, Govind Valecha, Rekha Shukla, Govind Kaushik, Deepak Rahman, Mohammad Akhlaquer Gautam, Rupesh K. Madan, Kumud Mittal, Vineet Singla, Rajeev K. Evid Based Complement Alternat Med Research Article Traumatic brain injuries due to sudden accidents cause major physical and mental health problems and are one of the main reasons behind the mortality and disability of patients. Research on alternate natural sources could be a boon for the rehabilitation of poor TBI patients. The literature indicates the Marrubium vulgare Linn. and its secondary metabolite marrubiin (furan labdane diterpene) possess various pharmacological properties such as vasorelaxant, calcium channel blocker, antioxidant, and antiedematogenic activities. Hence, in the present research, both marrubiin and hydroalcoholic extracts of the plant were evaluated for their neuroprotective effect after TBI. The neurological severity score and oxidative stress parameters are significantly altered by the test samples. Moreover, the neurotransmitter analysis indicated a significant change in GABA and glutamate. The histopathological study also supported the observed results. The improved neuroprotective potential of the extract could be attributed to the presence of a large number of secondary metabolites including marrubiin. Hindawi 2022-05-24 /pmc/articles/PMC9155918/ /pubmed/35656476 http://dx.doi.org/10.1155/2022/4457973 Text en Copyright © 2022 Nidhi et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Nidhi, Singh, Govind Valecha, Rekha Shukla, Govind Kaushik, Deepak Rahman, Mohammad Akhlaquer Gautam, Rupesh K. Madan, Kumud Mittal, Vineet Singla, Rajeev K. Neurobehavioral and Biochemical Evidences in Support of Protective Effect of Marrubiin (Furan Labdane Diterpene) from Marrubium vulgare Linn. and Its Extracts after Traumatic Brain Injury in Experimental Mice |
title | Neurobehavioral and Biochemical Evidences in Support of Protective Effect of Marrubiin (Furan Labdane Diterpene) from Marrubium vulgare Linn. and Its Extracts after Traumatic Brain Injury in Experimental Mice |
title_full | Neurobehavioral and Biochemical Evidences in Support of Protective Effect of Marrubiin (Furan Labdane Diterpene) from Marrubium vulgare Linn. and Its Extracts after Traumatic Brain Injury in Experimental Mice |
title_fullStr | Neurobehavioral and Biochemical Evidences in Support of Protective Effect of Marrubiin (Furan Labdane Diterpene) from Marrubium vulgare Linn. and Its Extracts after Traumatic Brain Injury in Experimental Mice |
title_full_unstemmed | Neurobehavioral and Biochemical Evidences in Support of Protective Effect of Marrubiin (Furan Labdane Diterpene) from Marrubium vulgare Linn. and Its Extracts after Traumatic Brain Injury in Experimental Mice |
title_short | Neurobehavioral and Biochemical Evidences in Support of Protective Effect of Marrubiin (Furan Labdane Diterpene) from Marrubium vulgare Linn. and Its Extracts after Traumatic Brain Injury in Experimental Mice |
title_sort | neurobehavioral and biochemical evidences in support of protective effect of marrubiin (furan labdane diterpene) from marrubium vulgare linn. and its extracts after traumatic brain injury in experimental mice |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9155918/ https://www.ncbi.nlm.nih.gov/pubmed/35656476 http://dx.doi.org/10.1155/2022/4457973 |
work_keys_str_mv | AT nidhi neurobehavioralandbiochemicalevidencesinsupportofprotectiveeffectofmarrubiinfuranlabdanediterpenefrommarrubiumvulgarelinnanditsextractsaftertraumaticbraininjuryinexperimentalmice AT singhgovind neurobehavioralandbiochemicalevidencesinsupportofprotectiveeffectofmarrubiinfuranlabdanediterpenefrommarrubiumvulgarelinnanditsextractsaftertraumaticbraininjuryinexperimentalmice AT valecharekha neurobehavioralandbiochemicalevidencesinsupportofprotectiveeffectofmarrubiinfuranlabdanediterpenefrommarrubiumvulgarelinnanditsextractsaftertraumaticbraininjuryinexperimentalmice AT shuklagovind neurobehavioralandbiochemicalevidencesinsupportofprotectiveeffectofmarrubiinfuranlabdanediterpenefrommarrubiumvulgarelinnanditsextractsaftertraumaticbraininjuryinexperimentalmice AT kaushikdeepak neurobehavioralandbiochemicalevidencesinsupportofprotectiveeffectofmarrubiinfuranlabdanediterpenefrommarrubiumvulgarelinnanditsextractsaftertraumaticbraininjuryinexperimentalmice AT rahmanmohammadakhlaquer neurobehavioralandbiochemicalevidencesinsupportofprotectiveeffectofmarrubiinfuranlabdanediterpenefrommarrubiumvulgarelinnanditsextractsaftertraumaticbraininjuryinexperimentalmice AT gautamrupeshk neurobehavioralandbiochemicalevidencesinsupportofprotectiveeffectofmarrubiinfuranlabdanediterpenefrommarrubiumvulgarelinnanditsextractsaftertraumaticbraininjuryinexperimentalmice AT madankumud neurobehavioralandbiochemicalevidencesinsupportofprotectiveeffectofmarrubiinfuranlabdanediterpenefrommarrubiumvulgarelinnanditsextractsaftertraumaticbraininjuryinexperimentalmice AT mittalvineet neurobehavioralandbiochemicalevidencesinsupportofprotectiveeffectofmarrubiinfuranlabdanediterpenefrommarrubiumvulgarelinnanditsextractsaftertraumaticbraininjuryinexperimentalmice AT singlarajeevk neurobehavioralandbiochemicalevidencesinsupportofprotectiveeffectofmarrubiinfuranlabdanediterpenefrommarrubiumvulgarelinnanditsextractsaftertraumaticbraininjuryinexperimentalmice |